Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies

McGranaghan, Peter; Kirwan, Jennifer; García-Rivera, Mariel A.; Pieske, Burkert; Edelmann, Frank; Blaschke, Florian; Appunni, Sandeep; Saxena, Anshul; Veledar, Emir; Trippel, Tobias Daniel

doi:10.3390/metabo11090621

Cited by 27 publications

(24 citation statements)

References 169 publications

(167 reference statements)

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“…Thus far, the pathomechanisms of CVD are mainly attributed to atherosclerosis, oxidative stress, and inflammation [ 13 , 24 ]. It is well known that the deposition of TAGs and cholesterol attributes to the pathogenesis of atherosclerosis.…”

Section: Resultsmentioning

confidence: 99%

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Lipidomics Revealed Aberrant Lipid Metabolism Caused by Inflammation in Cardiac Tissue in the Early Stage of Systemic Lupus Erythematosus in a Murine Model

Zhang

Tian

et al. 2022

Metabolites

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Cardiac involvement, displayed as premature cardiovascular disease (CVD), is one of common clinical symptoms of patients with systemic lupus erythematosus (SLE), contributing to mortality of the disease. The precise underlying pathological mechanism(s) for the cardiac involvement in lupus remains poorly understood. Lipids and their metabolites are directly involved in atherosclerosis development, oxidative stress, and inflammation, which are closely related to the development of CVD. In the study, shotgun lipidomics was exploited to quantitatively analyze cellular lipidomes in the cardiac tissue of MRL/lpr mice at two different time points (i.e., pre-lupus and lupus state) with/without treatment with glucocorticoids (GCs). Urine protein, spleen index, and renal histopathological evaluation of the mice were also performed for assessment of SLE onset and/or outcome. Lipidomics analysis revealed that the deposition of cholesterol and the aberrant metabolism of lipids caused by the increased energy metabolism and the enhanced activation of phospholipases, both of which were originally induced by inflammation, were already present in cardiac tissues from lupus-prone mice even at pre-lupus state. These lipid alterations could further induce inflammation and autoimmune responses, accelerating the process of CVD. In addition, the present study also demonstrated that GCs therapy could not only delay the progression of SLE, but also partially corrected these alterations of lipid species in cardiac tissue due to their anti-inflammatory effect. Thus, the medications with better anti-inflammatory effect might be a useful therapeutic method for premature CVD of SLE.

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Section: Resultsmentioning

confidence: 99%

“…Usually, atherosclerosis development, oxidative stress, and inflammation play important roles in pathogenesis of CVD [ 13 ]. In addition to serving as essential components of cell membranes and playing key roles in cellular functions, lipids and their metabolisms are directly involved in these processes.…”

Section: Introductionmentioning

confidence: 99%

Lipidomics Revealed Aberrant Lipid Metabolism Caused by Inflammation in Cardiac Tissue in the Early Stage of Systemic Lupus Erythematosus in a Murine Model

Zhang

Tian

et al. 2022

Metabolites

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“…Because of the inherent sensitivity to even subtle changes in the actual phenotype, metabolomics is steadily gaining popularity in different areas of medical research. Altered lipid metabolism in CV disease (CVD), in particular, has been the focus of a number of recent studies [ 8 , 56 ]. Metabolomic profiling seems to improve both the risk stratification and early identification of CVD.…”

Section: Brief Overview Of Metabolomicsmentioning

confidence: 99%

Metabolomics of Arterial Stiffness

Paapstel

Kals

2022

Metabolites

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Arterial stiffness (AS) is one of the earliest detectable signs of structural and functional alterations of the vessel wall and an independent predictor of cardiovascular events and death. The emerging field of metabolomics can be utilized to detect a wide spectrum of intermediates and products of metabolism in body fluids that can be involved in the pathogenesis of AS. Research over the past decade has reinforced this idea by linking AS to circulating acylcarnitines, glycerophospholipids, sphingolipids, and amino acids, among other metabolite species. Some of these metabolites influence AS through traditional cardiovascular risk factors (e.g., high blood pressure, high blood cholesterol, diabetes, smoking), while others seem to act independently through both known and unknown pathophysiological mechanisms. We propose the term ‘arteriometabolomics’ to indicate the research that applies metabolomics methods to study AS. The ‘arteriometabolomics’ approach has the potential to allow more personalized cardiovascular risk stratification, disease monitoring, and treatment selection. One of its major goals is to uncover the causal metabolic pathways of AS. Such pathways could represent valuable treatment targets in vascular ageing.

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“…Plasma has been the most studied biofluid in this disease and is expected to reflect changes that occur in other tissues and organs, such as the brain. This is important in the case of MDD, where major modifications are expected to occur in the brain, that is inaccessible for molecular and biochemical analysis [63]. The accessibility of plasma makes it preferable to identify markers of lipids altered in MDD.…”

Section: Changes In Lipidome Associated With Major Depressive Disorde...mentioning

confidence: 99%

Adaptation of Lipid Profiling in Depression Disease and Treatment: A Critical Review

Pinto

Conde

Domingues

et al. 2022

IJMS

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Major depressive disorder (MDD), also called depression, is a serious disease that impairs the quality of life of patients and has a high incidence, affecting approximately 3.8% of the world population. Its diagnosis is very subjective and is not supported by measurable biomarkers mainly due to the lack of biochemical markers. Recently, disturbance of lipid profiling has been recognized in MDD, in animal models of MDD or in depressed patients, which may contribute to unravel the etiology of the disease and find putative new biomarkers, for a diagnosis or for monitoring the disease and therapeutics outcomes. In this review, we provide an overview of current knowledge of lipidomics analysis, both in animal models of MDD (at the brain and plasma level) and in humans (in plasma and serum). Furthermore, studies of lipidomics analyses after antidepressant treatment in rodents (in brain, plasma, and serum), in primates (in the brain) and in humans (in plasma) were reviewed and give evidence that antidepressants seem to counteract the modification seen in lipids in MDD, giving some evidence that certain altered lipid profiles could be useful MDD biomarkers for future precision medicine.

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Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies

Cited by 27 publications

References 169 publications

Lipidomics Revealed Aberrant Lipid Metabolism Caused by Inflammation in Cardiac Tissue in the Early Stage of Systemic Lupus Erythematosus in a Murine Model

Lipidomics Revealed Aberrant Lipid Metabolism Caused by Inflammation in Cardiac Tissue in the Early Stage of Systemic Lupus Erythematosus in a Murine Model

Metabolomics of Arterial Stiffness

Adaptation of Lipid Profiling in Depression Disease and Treatment: A Critical Review

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