Lipid Metabolism in Brain During Myelination

Waelsch, Heinrich; Sperry, Warren M.; Stoyanoff, V.A.

doi:10.1016/s0021-9258(18)73187-6

Cited by 117 publications

(2 citation statements)

References 11 publications

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“…The processes that maintain cholesterol homeostasis in the healthy brain are not static, but change during early human development and later again in the aging brain. Cholesterol synthesis rates are at the highest-level during brain development to support the generation of an extensive neuronal network ( Waelsch et al, 1940 ; Quan et al, 2003 ; Pfrieger and Ungerer, 2011 ). Therefore, all brain cell types, including both neurons and glial cells are thought to contribute to cholesterol biosynthesis during development ( Pfrieger and Ungerer, 2011 ; Genaro-Mattos et al, 2019 ).…”

Section: Brain Cholesterol Metabolism; Changes From Development To Agingmentioning

confidence: 99%

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Feringa

Kant

2021

Front. Aging Neurosci.

140

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While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body’s cholesterol. Cholesterol levels in the brain are tightly regulated for physiological brain function, but mounting evidence indicates that excessive cholesterol accumulates in Alzheimer’s disease (AD), where it may drive AD-associated pathological changes. This seems especially relevant for late-onset AD, as several of the major genetic risk factors are functionally associated with cholesterol metabolism. In this review we discuss the different systems that maintain brain cholesterol metabolism in the healthy brain, and how dysregulation of these processes can lead, or contribute to, Alzheimer’s disease. We will also discuss how AD-risk genes might impact cholesterol metabolism and downstream AD pathology. Finally, we will address the major outstanding questions in the field and how recent technical advances in CRISPR/Cas9-gene editing and induced pluripotent stem cell (iPSC)-technology can aid to study these problems.

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Section: Brain Cholesterol Metabolism; Changes From Development To Agingmentioning

confidence: 99%

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Feringa

Kant

2021

Front. Aging Neurosci.

140

View full text Add to dashboard Cite

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“…First evidence that brain cells synthesize cholesterol has been published 60 years ago by the group of Heinrich Waelsch. Their pioneering use of heavy water to study lipid synthesis in rats indicated that cholesterol is synthesized in the brain and that the rate of synthesis is higher during early postnatal development than in adult animals [55,56]. Using similar methods and thorough quantification, Quan and colleagues revealed that cholesterol synthesis in the developing mouse brain peaks during the second postnatal week and varies across regions.…”

Section: Cholesterol Synthesis In the Brainmentioning

confidence: 99%