Lipid Metabolism Genes in Stroke Pathogenesis: The Atherosclerosis

Chow, Yit-Lai; Teh, Lai Kuan; Chyi, Loh Huey; Lim, Li Fang; Yee, Chin Chu; Wei, Loo Keat

doi:10.2174/1381612826666200614180958

Cited by 21 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The underlying mechanism of the synergistic interaction is still unclear, but studies have confirmed that atherosclerosis is the leading cause of increased stroke-related mortality [ 36 ]. As a progressive inflammatory disease, atherosclerosis is caused by deposit/plaque accumulation in the intima of blood vessels, which causes arterial narrowing [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

Wang

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Hyperlipidemia (HLP) and hypertension (HTN) are both independent risk factors for ischemic stroke. This study aimed to assess whether HTN and HLP have a synergistic effect on the risk of ischemic stroke. Methods Between January and August 2013, 11,695 subjects in rural areas of northeastern China were enrolled. The additive and multiplicative scales were used to evaluate the interaction. Results The prevalence of ischemic stroke was 5.7%. Using the healthy group (without HTN or HLP) as the reference group, subjects with both HTN and HLP had a higher risk of ischemic stroke (odds ratio [OR]: 3.369, 95% confidence interval [CI]: 2.579–4.402), and this OR was greater than that of subjects with only HTN (OR: 1.995, 95% CI 1.526–2.610) or HLP (OR: 1.321, 95% CI 0.937–1.862) (adjusting for age, sex, race, education level, family income, current smoking and drinking status, physical activity, body mass index, diabetes, family history of stroke, and atrial fibrillation). Regarding the additive scale, the relative excess risk due to interaction (OR: 1.053, 95% CI 0.458–1.648) was positive after adjusting for confounders. Moreover, the attributable proportion was 31.3%, which means that 31.3% of the total risk of ischemic stroke was due to the synergistic interaction between HTN and HLP. Furthermore, the synergistic index (S) of ischemic stroke was 1.8 (95% CI 1.157–2.801), which also indicates a synergistic interaction between HTN and HLP. Regarding the multiplicative scale, the interaction effect was also significant after adjusting for confounders (OR: 2.163, 95% CI 1.817–2.575). Conclusion The results suggest that the synergistic effect of HTN and HLP on ischemic stroke is significantly higher than the sum of their independent effects. The quantification of the combined effect should help to promote healthy blood pressure and blood lipid levels among the general population.

show abstract

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

Wang

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Lipid metabolism related genes, namely LMRGs, as the second messenger of intracellular signal transduction, lipids behave essential roles in different organelles ( Efeyan et al, 2015 ). Researches about LMRGs were widely conducted in various diseases like degenerative alterations, atherosclerosis, diabetes, and different kinds of cancers ( Santos and Schulze, 2012 ; Johnson and Stolzing, 2019 ; Chow et al, 2020 ; Thongnak et al, 2020 ). Recent years, LMRGs reprogramming has also been regarded as a novel hallmark of tumor malignancy, and the pivotal roles of LMRGs in the initiation, progression, and treatment of tumors have been proved ( Cheng et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The Roles of Blood Lipid-Metabolism Genes in Immune Infiltration Could Promote the Development of IDD

Ding

Zhang

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Objectives: Intervertebral disc degeneration is a progressive and chronic disease, usually manifesting as low back pain. This study aimed to screen effective biomarkers for medical practice as well as figuring out immune infiltration situations between circulation and intervertebral discs.Methods: Gene expression profiles of GSE124272 was included for differentially analysis, WGCNA and immune infiltration analysis from GEO database, and other GSE series were used as validation datasets. A series of validation methods were conducted to verify the robustness of hub genes, such as principal component analysis, machine learning models, and expression verification. Lastly, nomogram was established for medical practice.Results: 10 genes were commonly screened via combination of DEGs, WGCNA analysis and lipid metabolism related genes. Furthermore, 3 hub gens CYP27A1, FAR2, CYP1B1 were chosen for subsequent analysis based on validation of different methods. GSEA analysis discovered that neutrophil extracellular traps formation and NOD-like receptor signaling pathway was activated during IDD. Immune infiltration analysis demonstrated that the imbalance of neutrophils and γδT cells were significantly correlated with IDD progression. Nomogram was established based on CYP27A1, FAR2, CYP1B1 and age, the calibration plot confirmed the stability of our model.Conclusion: CYP27A1, FAR2, CYP1B1 were considered as hub lipid metabolism related genes (LMRGs) in the development of IDD, which were regarded as candidate diagnostic biomarkers especially in circulation. The effects are worth expected in the early diagnosis of IDD through detecting these genes in blood.

show abstract

“…Stroke is the main clinical type of cerebrovascular disease. Among them, atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related mortality [ 2 ]. Plaque rupture and thrombosis result in the acute clinical complications of stroke.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Oxidative Stress: An Important Molecular Mechanism of Chinese Herbal Medicine (Astragalus membranaceus, Carthamus tinctorius L., Radix Salvia Miltiorrhizae, etc.) in the Treatment of Ischemic Stroke by Regulating the Antioxidant System

Zhao

Zhang

Wan

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. Traditional Chinese medicine (TCM) has been utilized for thousands of years in China and is becoming increasingly popular all over the world, especially for the treatments of ischemic stroke. More and more evidences have implicated that oxidative stress has been closely related with ischemic stroke. This review will concentrate on the evidence of the action mechanism of Chinese herbal medicine and its active ingredient in preventing ischemic stroke by modulating redox signaling and oxidative stress pathways and providing references for clinical treatment and scientific research applications.

show abstract

Lipid Metabolism Genes in Stroke Pathogenesis: The Atherosclerosis

Cited by 21 publications

References 0 publications

Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

The Roles of Blood Lipid-Metabolism Genes in Immune Infiltration Could Promote the Development of IDD

Inhibition of Oxidative Stress: An Important Molecular Mechanism of Chinese Herbal Medicine (Astragalus membranaceus, Carthamus tinctorius L., Radix Salvia Miltiorrhizae, etc.) in the Treatment of Ischemic Stroke by Regulating the Antioxidant System

Contact Info

Product

Resources

About