Lipid metabolism disorders and lipid mediator changes of mice in response to long-term exposure to high-fat and high sucrose diets and ameliorative effects of mulberry leaves

Abstract

Improvement of n-3 PUFA metabolism disorders plays an important role in anti-obesity modulated by mulberry leaves.

Comprehensive lipidomic analysis revealed the effects of fermented Morus alba L. intake on lipid profile in backfat and muscle tissue of Yuxi black pigs

“…Related studies have found that mulberry leaf water extract can reduce the serum free fatty acid level in hyperglycemic mice (Han et al, 2020). Subsequently, studies have shown that the content of eleven long‐chain fatty acids was significantly reversed in high‐fat diet mice fed with mulberry leaves, this corresponds to our experimental results (Du et al, 2022b). In addition, we noticed that TG had more long‐chain fatty acids in muscle tissue, while TG had more short‐chain fatty acids in fat, which may be related to the presence of some brown fat in muscle, and the activation of UCP1 in brown fat requires long‐chain fatty acids, which corresponds to the presence of more long‐chain fatty acids in muscle (Zhao et al, 2017).…”

“…Mulberry leaf is a plant of the genus Mulberry, which is widely distributed in southwest China, Japan, Korea, Europe, and other regions. Mulberry leaf is rich in flavonoids, alkaloids, phenolic acids, and other components, (Srivastava et al, 2003; Zhang et al, 2022) and has hypoglycaemia, lipid‐lowering antioxidant, and other effects (Du et al, 2022a; Liao et al, 2021). Furthermore, mulberry leaves are widely used as functional food and beverage in many Asian countries such as China and Japan (Eva María Sánchez‐Salcedo & Amorós, 2017).…”

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

“…Mulberry leaf tea has been recorded for diabetes treatment in “ Compendium of Materia Medica ,” which was booked by the pharmacist Shi‐Zhen Li of the Ming Dynasty in ancient China. Recently, our group has demonstrated that mulberry leaf water or ethanol extracts can improve lipid metabolism disorder, glucose homeostasis, inflammation, oxidative stress, insulin secretion, and gut microbiota imbalance in high‐fat diet and/or streptozotocin (STZ)‐induced obese or type 2 diabetic mice (Du, Li, Lu, Zhang, Zhao, et al, 2022; Du, Li, Lu, Zhang, Zheng, 2002; Du, Li, Lu, Zhang, Zhong, et al, 2022; Ji et al, 2021). However, studies about the impact of mulberry leaf on BCAAs metabolism and relative gut microbiota in T2DM are still limited.…”

The Effect of Guisangyou Tea on Abnormal Lipid Metabolism in Mice Induced by High-Fat Diet

“…Mulberry leaf polyphenols can inhibit body weight and fat accumulation in mice with obesity induced by a HFD, and have potential lipid-lowering and weight-loss effects [14]. Mulberry leaves can also ameliorate lipid metabolism disorders in mice fed a long-term high-fat and high-sugar diet and possess blood-lipid-lowering, antioxidant, and anti-inflammatory properties [15].…”