Lipid Metabolism as a Potential Target of Liver Cancer

Abstract

Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.

GDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications

“… 83 , 88 Immunohistochemistry (IHC) testing shows increased GDF15 expression in moderate to severe HCC, correlating with pathological grading, but not with age, gender, or tumor node metastasis (TNM) stage. 29 , 89 The Barcelona Clinic Liver Cancer (BCLC) system, the most reliable staging method for HCC, includes five stages: stage 0 (extremely early), stage A (early), stage B (intermediate), stage C (advanced), and stage D (end-stage). 84 , 90 A study by Chen et al found elevated GDF15 levels in patients with BCLC-B and BCLC-C compared to healthy individuals and those with BCLC-A.…”