Lipid metabolism and retinoid therapy

Marsden, J.R.

doi:10.1016/0163-7258(89)90074-0

Cited by 33 publications

(12 citation statements)

References 37 publications

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“…The triacylglycerol concentration in serum was not significantly increased in these patients (tab. 2), possibly because Roaccutane™ dose was relatively low (21), or because we missed the increase due to the design of the experiment.…”

Section: Discussionmentioning

confidence: 91%

In Vivo Effects of 13-cis Retinoic Acid Treatment on the Concentration of Proteins and Lipids in Serum

Fex

Aronsson²,

Andersson³

et al. 1996

CCLM

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A number of serum components, whose concentrations or gene expression have been shown to be modulated by all-trans retinoic acid in vitro, were monitored in patients before and during treatment with Roaccutane™ (13-c/s retinoic acid, 40-60 mg/day) for severe acne. The 13-cis retinoic acid concentration in serum rose from 5.25 ± 1.09 to 593 ± 65 nmol/1 (mean ± SD) 24 h after the latest dose. The concentration of all-trans retinoic acid in serum under Roaccutane™ treatment was measured in model experiments and shown to be 10-20 nmol/1 i.e., 2-4 times the basal levels (4.65 ± 0.85 nmol/1) when the 13-cis retinoic acid concentration was 370-980 nmol/1. The concentrations of creatine kinase-MB, apolipoprotein B, total cholesterol and LDL cholesterol increased significantly while the other measured serum components, including lipoprotein lipase activity, were unaffected by Roaccutane™ treatment.

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Section: Discussionmentioning

confidence: 91%

In Vivo Effects of 13-cis Retinoic Acid Treatment on the Concentration of Proteins and Lipids in Serum

Fex

Aronsson²,

Andersson³

et al. 1996

CCLM

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“…This is similar to the metabolic abnormality seen in familial combined hyperlipidaemia. In addition, there is an increased degradation of LDL-rich cholesterol (Marsden 1989).…”

Section: Effects On Lipid Metabolismmentioning

confidence: 99%

Adverse Reactions to Oral Retinoids An Update

Mills

Marks

1993

Drug Safety

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Retinoids, both naturally occurring and synthetic, are analogues of vitamin A. They represent a major advance in the treatment of acne and psoriasis, as well as rarer conditions such as the ichthyoses. The more frequent and widespread use of these drugs requires that the dermatologist be aware of the wide spectrum of adverse events that may be encountered with their use. Some are serious and irreversible, such as teratogenicity, necessitating great care if these drugs are given to women of childbearing potential. Other effects may be less severe, dose dependent and reversible. Although not devastating to the patient, appropriate advice may reduce morbidity.

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“…In humans, vitamin A derivative, isotretinoin (13‐ cis ‐RA) is shown to be effective in the treatment of dermatological diseases, but a side‐effect of treatment with retinoids is hyperlipidemia. In general, very low density lipoprotein (VLDL) triglyceride levels and cholesterol levels, predominantly contained in low density lipoproteins (LDL), as well as apoB‐100 levels, are increased after long‐term isotretinoin treatment [8–11]. Little or no changes in HDL‐cholesterol, apoA‐I and apoA‐II are found [8–11].…”

Section: Effect Of Treatment With Placebo or Isotretinoin On Concentrmentioning

confidence: 99%

No short‐term effect of oral isotretinoin (13‐cis retinoic acid) on lipoprotein(a) and HDL subclasses LP‐A‐I and LP‐A‐I:A‐II in healthy volunteers

Neele¹,

Buytenhek²,

Staels

et al. 1999

Journal of Internal Medicine

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Lipid metabolism and retinoid therapy

Cited by 33 publications

References 37 publications

In Vivo Effects of 13-cis Retinoic Acid Treatment on the Concentration of Proteins and Lipids in Serum

In Vivo Effects of 13-cis Retinoic Acid Treatment on the Concentration of Proteins and Lipids in Serum

Adverse Reactions to Oral Retinoids An Update

No short‐term effect of oral isotretinoin (13‐cis retinoic acid) on lipoprotein(a) and HDL subclasses LP‐A‐I and LP‐A‐I:A‐II in healthy volunteers

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