Lipid Metabolism—An Aberrant Shift in Cancer: A Narrative Review

Abstract

Cancer is a multifactorial disease characterized by uncoordinated proliferation and growth of tumor cells. To survive, cancer cell undergoes various metabolic reprogramming by changes in the pathways. The role of glucose and amino acid metabolism in cancer has been studied extensively. However, lipid metabolism and its role in cancer are less explored. The concept of lipid metabolism has gained attention of researchers to discover its importance in understating the need of lipids for tumor cell growth and survival through various mechanisms to help us for improvising therapeutic strategies. Hence, in this review, we have highlighted the pivotal role of lipid metabolism in normal cell and cancer cell with illustrations.