Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis

Brouwers, Hilde; Hegedus, Joost von; Toes, René E. M.; Kloppenburg, Margreet; Ioan‐Facsinay, Andreea

doi:10.1016/j.berh.2016.02.003

Cited by 71 publications

(61 citation statements)

References 112 publications

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“…Similar to our conclusion, Jeong's study also suggested these favorable outcomes could be associated with the inhibitory effects on FLS [25]. But to the contrary, some scholars deemed free fatty acids as potential proinflammatory mediators in rheumatic diseases [26,27], and Lima-Salgado et al found fatty acid promoted TNF-a production in mouse macrophage [28]. For diverse results were observed in separate studies, to figure out what drives to the opposite outcomes is with great interest for further researches.…”

Section: Discussionsupporting

confidence: 86%

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

Jiang

Yang

et al. 2018

The Kaohsiung J of Med Scie

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Securidaca inappendiculata Hassk. (SI) is a medicinal plant used to treat rheumatoid arthritis (RA) in South China. A substantial amount of fatty oil was isolated from SI (SIF), however little knowledge about its chemical composition and medicinal potentials was obtained. In this study, we analyzed its chemical composition with methyl esterification based GC–MS method, and investigated the therapeutic potentials on adjuvant‐induced arthritis (AA) in mice. MTT and western‐blot methods were employed to investigate its effects on proliferation rate and protein expressions in MH7A cells, respectively. It was revealed SIF was mainly comprised of saturated and monosaturated fatty acids, and the two predominant compounds were palmitic acid (36.89%) and oleic acid (31.12%). Treatment with SIF at 100 mg/kg resulted in significant alleviation of AA severity in mice, together with reduced synovial hyperplasia and inflammatory infiltration in joints, and decreased levels of sialic acid, malondialdehyde and alkaline phosphatase in serum. Results from immunohistochemical assays hinted the protective effects of SIF on joints were associated to the inhibition on production of some pathological factors in synovium, including IL‐1β, TNF‐α and MMP‐9. SIF inhibited the proliferation of MH7A cells in a concentration dependent manner, and abrogated phosphorylation of p65 in vitro. These evidences collectively suggested SIF could suppress the pathological functions of fibroblast‐like synoviocyte, and protect joints from destruction under AA conditions.

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Section: Discussionsupporting

confidence: 86%

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

Jiang

Yang

et al. 2018

The Kaohsiung J of Med Scie

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“…Eicosanoids are the product of oxygenation of arachidonic acid and play a significant role in multiple pathological processes including atherosclerosis, asthma, and rheumatoid arthritis(1–3). Pharmacological targeting of eicosanoid production is a well-established therapeutic tool.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration

Yonker

Pazos

Lanter

et al. 2017

The Journal of Immunology

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Eicosanoids are a group of bioactive lipids, shown to be important mediators of neutrophilic inflammation, and selective targeting of their function confers therapeutic benefit in a number of diseases. Neutrophilic airway diseases, including cystic fibrosis, are characterized by excessive neutrophil infiltration into the airspace. Understanding the role of eicosanoids in this process may reveal novel therapeutic targets. The eicosanoid hepoxilin A3 (HxA3) is a pathogen-elicited, epithelial-produced neutrophil chemoattractant that directs trans-epithelial migration in response to infection. Following HxA3-driven trans-epithelial migration, neutrophil chemotaxis is amplified through neutrophil production of a second eicosanoid, leukotriene B4 (LTB4). The rate-limiting step of eicosanoid generation is the liberation of arachidonic acid by phospholipase A2 (PLA2), and the cytosolic PLA2α (cPLA2α) isoform has been specifically shown to direct LTB4 synthesis in certain contexts. Whether cPLA2α is directly responsible for neutrophil synthesis of LTB4 in the context of Pseudomonas aeruginosa-induced neutrophil trans-epithelial migration has not been explored. Human and mouse neutrophil-epithelial co-cultures were employed to evaluate the role of neutrophil-derived cPLA2α in infection-induced trans-epithelial signaling using pharmacological and genetic approaches. Primary human airway basal stem cell-derived epithelial cultures and micro-Optical Coherence Tomography (μOCT), a new imaging modality that captures two- and three-dimensional real-time dynamics of neutrophil trans-epithelial migration, were applied. Evidence from these studies suggests that cPLA2α expressed by neutrophils, but not epithelial cells, plays a significant role in infection-induced neutrophil trans-epithelial migration by mediating leukotriene B4 synthesis during migration, which serves to amplify the magnitude of neutrophil recruitment in response to epithelial infection.

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“…Epidemiology data demonstrates that the incidence of OA in middle aged and elderly population >40 years reaches 46.3%, of these 80% demonstrate limited joint mobility (3). Effective therapy to prevent and cure OA requires understanding of the pathogenesis, however, the etiological agent of osteoarthritis remains to be elucidated despite previous studies suggesting that OA is associated with numerous factors, including senility, obesity, inflammation, trauma and heredity (4,5).…”

Section: Introductionmentioning

confidence: 99%

Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling

Wang

Jin

et al. 2016

Molecular Medicine Reports

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Abstract. Puerarin is an important active ingredient in the root of kudzu vine due to its pharmacological properties. The aim of the present study is to contribute to the existing knowledge of the effect of puerarin in the attenuation of inflammation and oxidation in mice with collagen antibody-induced arthritis via toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling. Arthritis was induced using injection of anti-type II collagen antibodies. Treatment with puerarin was observed to significantly decrease clinical scoring of the collagen antibody-induced arthritis and suppress oxidative stress and the inflammatory response in mice. Furthermore, puerarin was demonstrated to inhibit mRNA expression of matrix metalloproteinase-9 and protein expression of TLR4 following collagen antibody-induced arthritis in mice. The effect of puerarin may be associated with the suppression of NF-κB activity in collagen antibody-induced arthritis mice. Furthermore, upregulation of phosphorylated (p)-Janus kinase 2 and p-signal transducer and activator of transcription 3 protein expression was suppressed by puerarin. The results of the present study indicate, for the first time, the effect of puerarin to attenuate inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling.

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Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis

Cited by 71 publications

References 112 publications

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration

Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling

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