Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes

Shivakoti, Rupak; Dalli, Jesmond; Kadam, Dileep; Gaikwad, Sanjay; Barthwal,; Colas, Romain A.; Mazzacuva, Francesca; Lokhande, Rahul; Dharmshale, Sujata; Bharadwaj, Renu; Kagal, Anju; Pradhan, Neeta; Deshmukh, Sanjay D; Atre, Sachin; Sahasrabudhe, Tushar; Kakrani, Arjun Lal; Kulkarni, Vandana; Raskar, Swapnil; Suryavanshi, Nishi; Chon, Sandy; Gupte, Akshay; Gupta, Amita; Gupte, Nikhil; Arriaga, María B.; Fukutani, Kiyoshi F.; Andrade, Bruno B.; Golub, Jonathan E.; Mave, Vidya

doi:10.1016/j.prostaglandins.2019.106398

Cited by 25 publications

(23 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such an effect of DM in the resolution of inflammation has been shown in other diseases. For example, an imbalance of proinflammatory and pro-resolving mediators was observed in DM patients with tuberculosis [ 33 ]. A study on DM-associated retina damage showed that hyperglycemia may decrease RvD1 in the retina [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis

Miao

Tang

Schultzberg

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Background. Diabetes mellitus (DM) aggravates symptoms and prognosis of acute ischemic stroke (AIS), and inflammation plays an important role therein. Resolvin D2 (RvD2) is one of the specialized pro-resolving mediators (SPMs), while leukotriene B4 (LTB4) is a classic proinflammatory mediator. The ratio of RvD2 to LTB4 is an index of pro-resolving/proinflammatory balance. We aim to explore the role of RvD2/LTB4 ratio in ischemic stroke complicated with DM. Methods. The plasma levels of RvD2 and LTB4 were analyzed by enzyme immunoassay in stroke patients with DM (DM + AIS group) or without DM (nonDM+AIS group). Patients were followed up at 90 days after stroke onset, and modified Rankin Score (mRS) was assessed. The association of RvD2/LTB4 ratio with stroke severity and prognosis was also analyzed. Results. The plasma levels of RvD2 were positively correlated to LTB4. The RvD2/LTB4 ratio in DM + AIS group was lower than that in the nonDM+AIS group. No correlation was found between the RvD2/LTB4 ratio and infarct size or NIHSS score. The RvD2/LTB4 ratio at baseline was significantly lower in the poor prognosis group ( mRS ≥ 3 ) than that in the good prognosis group ( mRS ≤ 2 ). Conclusions. Our study indicated that the balance between pro-resolving and proinflammatory mediators was impaired by diabetes in ischemic stroke. The RvD2/LTB4 ratio may serve as a biomarker of prognosis for ischemic stroke.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis

Miao

Tang

Schultzberg

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…To estimate the dietary patters of our study participants, we employed a method adapted from ecology studies [ 21 , 22 ]. By transforming the total consumption of each food group (annotated in grams) into abundance of consumption in the diet, it was possible to infer the representativeness of ingestion of a given food group relative to total diet.…”

Section: Discussionmentioning

confidence: 99%

“…To evaluate the overall profile of consumption of the different food groups in the sample, data on total consumption in grams was transformed into abundance of consumption relative to total diet. This method has been commonly used in ecological analysis, in which proportion of each species is calculated to estimate representativeness [ 21 , 22 ]. Herein, this approach led us to define the proportion of consumption of each food or food group in the total ingestion of all the food groups (e.g., the percentage of the total ingestion that is represented by each food group).…”

Section: Methodsmentioning

confidence: 99%

Systems Nutrology of Adolescents with Divergence between Measured and Perceived Weight Uncovers a Distinctive Profile Defined by Inverse Relationships of Food Consumption

et al. 2020

Self Cite

View full text Add to dashboard Cite

Changes in food consumption, physical inactivity, and other lifestyle habits are potential causes of the obesity epidemic. Paradoxically, the media promotes idealization of a leaner body appearance. Under these circumstances, self-perception of weight by adolescents may be affected. Here, we performed a cross-sectional study, between June and December 2009, to evaluate the interaction between anthropometric status, perceived body weight, and food consumption profiles in 1496 adolescents from public schools in Salvador, Brazil. Data on socio-epidemiological information, anthropometric status, and dietary patterns were analyzed using multidimensional statistical approaches adapted from systems biology. There were dissimilarities between anthropometric status and perception of body weight related to sex. Four dietary patterns were identified based on the food intake profile in the study participants. The distinct dietary patterns were not influenced by divergence between measured and perceived weight. Moreover, network analysis revealed that overestimation of body weight was characterized by a selectivity in ingestion of food groups that resulted in appearance of inverse correlations of consumption. Thus, misperception of body weight is associated with inverse correlations of consumption of certain food groups. These findings may aid individualized nutritional interventions in adolescents who overestimate body weight.

show abstract

“…Recent studies have highlighted the impact of TB infection on systemic concentrations of different LMs, which persists even after anti-TB treatment (41)(42)(43). Apart from the important functions of LMs in the inflammatory response in TB, they also influence TB pathogenesis (41,42).…”

Section: Lipid Mediators In Tuberculosismentioning

confidence: 99%

The Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in Tuberculosis

et al. 2021

View full text Add to dashboard Cite

Host-directed therapies (HDTs) enhance the host response to tuberculosis (TB) infection to reduce disease severity. For instance, the manipulation of lipid mediator production diminishes the hyperactive immune response which is a known pathological feature of TB that generates lung tissue damage. Non-steroidal anti-inflammatory drugs (NSAIDs) and omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) are examples of such HDTs. In this mini-review, we recapitulate the literature available on the effects of NSAIDs and n-3 LCPUFA in TB as well as the immunological pathways underpinning these effects. Many NSAIDs have a great deal of data describing their effects and safety and in many jurisdictions are inexpensive, and sold over the counter in neighborhood convenience stores and supermarkets. The potential benefits of NSAIDs in TB are well-documented in pre-clinical studies. The reduction of pro-inflammatory lipid mediator production by inhibiting cyclooxygenase (COX) pathways with NSAIDs has been found to improve lung histopathology, bacterial control, and survival. Additionally, n-3 LCPUFA and its novel bioactive metabolites produced by COX and lipoxygenase (LOX) have been identified as safe and effective pro-resolving and antibacterial pharmaconutrients. Nevertheless, heterogeneous results have been reported in pre-clinical TB studies. Recently, the importance of the correct timing of NSAIDs and n-3 LCPUFA administration in TB has also been highlighted. This mini-review will provide a better understanding of the potential contribution of these therapies toward reducing inflammatory lung damage and improving bactericidal activity, especially during later stages of TB infection. It further highlights that clinical trials are required to confirm benefit and safety in TB patients.

show abstract

Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes

Cited by 25 publications

References 47 publications

Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis

Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis

Systems Nutrology of Adolescents with Divergence between Measured and Perceived Weight Uncovers a Distinctive Profile Defined by Inverse Relationships of Food Consumption

The Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in Tuberculosis

Contact Info

Product

Resources

About