Lipid mediators generated by the cytochrome P450—Epoxide hydrolase pathway

Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity

“… 94 As such, the in situ activity of sEH has been used as a proxy for pathogenicity and/or inflammation and inhibition of sEH activity has been associated with improved disease outcome, especially in pathologies involving the vascular endothelium in their etiology. 95 , 96 , 97 Despite being effective in diabetic retinopathy, 94 sEH inhibition does not modify insulin sensitivity 89 suggesting that CYP-sEH pathway acts on different levels in T2DM. 98 This is further supported by the multitude of pathways linked to sEH such as endothelial barrier function, ER stress, apoptosis and oxidative stress.…”

“…This is in line with what was described for adiponectin which enhances adipocyte lipid storage and adipogenesis, preventing ectopic lipid accumulation. 108 In general, a more comprehensive understanding of the role of fatty acid diols in adipose tissue, including their concentration-dependent actions, 95 will be key in understanding their implication during obesity.…”