Lipid mediated brain disorders: A perspective

Singh, Anju; Kukal, Samiksha; Kanojia, Neha; Singh, Mastan; Saso, Luciano; Kukreti, Shrikant; Kukreti, Ritushree

doi:10.1016/j.prostaglandins.2023.106737

Cited by 4 publications

(1 citation statement)

References 179 publications

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“…Some other researchers suggested the anti-oxidative potential Scrophularia amplexicaulis in inviro model of AD by increasing the cholinesterase activity (Hamedi et al, 2020). In the process of lipid peroxidation, many free radicals formed which damage the cell membranes (Singh et al, 2023). Enzymes like catalase and superoxide dismutase counteract this damage (Ali et al, 2022;Shi et al, 2022).…”

Section: Ad Pathogenesismentioning

confidence: 99%

Alzheimer’s Disease: Pathogenesis, Hypothesis and Management

Anjum

2023

PUJZ

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its prognosis is not entirely known. With the disease progression, individuals with AD may experience more severe symptoms like uncertainty, disorientation, agitation and behavioral and personality changes (Sano et al., 2023). In addition to cognitive symptoms, AD can also present with behavioral and psychological changes. These changes can include depression, anxiety, irritability, aggression, and psychosis (Heilman and Nadeau, 2022).A person with AD has brain alterations. It becomes smaller with time and has fewer healthy cells. β-amyloid plaques, which are clusters of protein that build up between the nerve cells rather than vanishing as they would in healthy brains and neurofibrillary tangles, which are twisted fibers inside brain cells that obstruct the movement of particles and other essential substances from one part of the cell to another, are two of the pathological Rabia AnjumAlzheimer's Disease: Pathogenesis, Hypothesis and Management

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Section: Ad Pathogenesismentioning

confidence: 99%

Alzheimer’s Disease: Pathogenesis, Hypothesis and Management

Anjum

2023

PUJZ

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Combining imaging mass spectrometry and immunohistochemistry to analyse the lipidome of spinal cord inflammation

Calvo,

Montilla,

Huergo

et al. 2024

Anal Bioanal Chem

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Inflammation is a complex process that accompanies many pathologies. Actually, dysregulation of the inflammatory process is behind many autoimmune diseases. Thus, treatment of such pathologies may benefit from in-depth knowledge of the metabolic changes associated with inflammation. Here, we developed a strategy to characterize the lipid fingerprint of inflammation in a mouse model of spinal cord injury. Using lipid imaging mass spectrometry (LIMS), we scanned spinal cord sections from nine animals injected with lysophosphatidylcholine, a chemical model of demyelination. The lesions were demonstrated to be highly heterogeneous, and therefore, comparison with immunofluorescence experiments carried out in the same section scanned by LIMS was required to accurately identify the morphology of the lesion. Following this protocol, three main areas were defined: the lesion core, the peri-lesion, which is the front of the lesion and is rich in infiltrating cells, and the uninvolved tissue. Segmentation of the LIMS experiments allowed us to isolate the lipid fingerprint of each area in a precise way, as demonstrated by the analysis using classification models. A clear difference in lipid signature was observed between the lesion front and the epicentre, where the damage was maximized. This study is a first step to unravel the changes in the lipidome associated with inflammation in the context of diverse pathologies, such as multiple sclerosis. Graphical abstract

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