Lipid-Lowering Efficacy of Red Yeast Rice in a Population Intolerant to Statins

Venero, Carmelo V.; Venero, Jose; Wortham, Dale C.; Thompson, Paul D.

doi:10.1016/j.amjcard.2009.10.045

Cited by 76 publications

(49 citation statements)

References 18 publications

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“…A recent study found that levels up to 200 ppm of citrinin do not seem to cause nephrotoxicity or hepatotoxicity in rats and suggested that levels of 2 ppm of citrin should be considered as minimal risk [47]. The daily dosage of red mold that has been found to effectively reduce LDL and total cholesterol levels is 1200 mg, or a dose where monacolin content is equal to 9.4 mg [44,45].…”

Section: Red Mold (Red Yeast Rice)mentioning

confidence: 96%

“…According to the traditional Chinese medicine pharmacopeia, it improves digestion and "revitalizes the blood" [43]. Research around red mold has focused on the ability of its metabolites (ie, monacolins and phytosterols) to effectively decrease both low-density lipoprotein (LDL) and total cholesterol levels in randomized controlled trials [44,45].…”

Section: Red Mold (Red Yeast Rice)mentioning

confidence: 99%

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Nutritional Supplements and Their Effect on Glucose Control

Lee

Dugoua

2011

Curr Diab Rep

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Type 2 diabetes is a growing health concern. The use of nutritional supplements by patients with type 2 diabetes is estimated at somewhere between 8% to 49%. The objective of this review was to search the scientific literature for advances in the treatment and prevention of type 2 diabetes with nutritional supplements. Twelve databases were searched with a focus on extracting studies published in the past 3 years. The following nutritional supplements were identified as potentially beneficial for type 2 diabetes treatment or prevention: vitamins C and E, α-lipoic acid, melatonin, red mold, emodin from Aloe vera and Rheum officinale, astragalus, and cassia cinnamon. Beta-carotene was shown to be ineffective in the prevention of type 2 diabetes. Ranging from preclinical to clinical, there is evidence that nutritional supplements may be beneficial in the treatment or prevention of type 2 diabetes. Health providers should investigate drug-nutritional supplement interactions prior to treatment.

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Section: Red Mold (Red Yeast Rice)mentioning

confidence: 96%

Section: Red Mold (Red Yeast Rice)mentioning

confidence: 99%

Nutritional Supplements and Their Effect on Glucose Control

Lee

Dugoua

2011

Curr Diab Rep

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“…Patients may fear the development of muscle pain because of anecdotes from friends or family, or from information they have read on the Internet [44]. Also, the preference of some patients for "natural products" could explain the better tolerability of red yeast rice [9].…”

Section: Controversiesmentioning

confidence: 99%

“…The third study was a retrospective analysis of 1,400 charts of patients with a history of statin intolerance [9].…”

Section: Role In Patients With Statin-associated Myalgiasmentioning

confidence: 99%

The Role of Red Yeast Rice for the Physician

Gordon

Becker

2010

Curr Atheroscler Rep

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Red yeast rice is an ancient Chinese dietary staple and medication used by millions of patients as an alternative therapy for hypercholesterolemia. In recent years, the use of red yeast rice has grown exponentially due to increased public interest in complementary and alternative medications and the publication of several randomized, controlled trials demonstrating its efficacy and safety in different populations. The most promising role for red yeast rice is as an alternative lipidlowering therapy for patients who refuse to take statins because of philosophical reasons or patients who are unable to tolerate statin therapy due to statin-associated myalgias. However, there is limited government oversight of red yeast rice products, wide variability of active ingredients in available formulations, and the potential of toxic byproducts. Therefore, until red yeast rice products are regulated and standardized, physicians and patients should be cautious in recommending this promising alternative therapy for hyperlipidemia.

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“…An excess of body fat, especially when it is localized in the abdominal region, leads to an imbalance of the metabolism of fats and sugars that induces hyperinsulinemia (high insulin level in the blood, an indicator of increased resistance to this hormone) [9,13]. In addition to strategies based on changing lifestyle, it is frequent utilization of natural substances, with beneficial properties [14][15][16][17][18]. Monacolin K of red rice (10 mg, 90% by policosanol) is able to inhibit the HMG-CoA reductase, which is a key enzyme in the biosynthesis of cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Effects of Monacolin K of Red Rice and Glucomannan, Combined with a Low Calorie Diet, in Treatment of Dyslipidemia and Hypertension

Esposito¹,

Allocca²,

Adelfi³

2015

Biol Med (Aligarh)

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Alarming increase in incidence of cardiovascular disease is result of a nutrition pattern characterized by an increase in consumption of fats, cholesterol, sugar and other refined carbohydrates, concomitant with low consumption of polyunsaturated fatty acids and fibers. The purpose of this study was to evaluate the efficacy of the monacolin K of red rice and glucomannan, associated with low-calorie diet, on improvement of lipid profile and hypertension, symptoms of metabolic syndrome. In 180 Neapolitan patients with metabolic syndrome, we evaluated effects of monacolin K of red rice and glucomannan, associated with a low-calorie diet, on total cholesterol (CT), LDL cholesterol (LDL), HDL cholesterol (HDL), triglycerides (TG) and blood pressure (BP). The results showed a significant decrease in average value of CT (-20%), LDL (-25%), TG (-20%), with an increase in HDL (+15%) and a decrease in BP (-20%). These findings corroborate evidences showing a therapeutic effects of these nutraceuticals in the treatment of dyslipidemia and hypertension, when a low-calorie diet alone is ineffective. B io lo g y and M e d ic in e

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Lipid-Lowering Efficacy of Red Yeast Rice in a Population Intolerant to Statins

Cited by 76 publications

References 18 publications

Nutritional Supplements and Their Effect on Glucose Control

Nutritional Supplements and Their Effect on Glucose Control

The Role of Red Yeast Rice for the Physician

Effects of Monacolin K of Red Rice and Glucomannan, Combined with a Low Calorie Diet, in Treatment of Dyslipidemia and Hypertension

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