Lipid Lowering Activity of<i>Anthocephalus indicus</i>Root in Hyperlipidemic Rats

Kumar, Vishnu; Khan, M. M. Abid Ali; Khanna, Ashok; Singh, Ranjana; Singh, Sushma; Chander, Ramesh; Mahdi, Farzana; Mahdi, Abbas Ali; Saxena, Jitendra Kumar; Singh, Raj Kumar

doi:10.1093/ecam/nen001

Cited by 22 publications

(9 citation statements)

References 19 publications

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“…This result may be due to there are fiber and other compounds as photochemical in defatted soy flour and dried mushroom which had hypercholesterolemic lowering effect in serum lipids. All these results consent with those of EL-Bastawesy and Hareedy (2004) and Kumar, et al (2009) who indicated that hepatic and serum total cholesterol, triglycerides, phospholipids and total lipids levels of rats fed on a high fat diet containing cholesterol and/or bile salts were significantly increased in hypercholesterolemic comparing to control animals receiving vehicle or normal diet. With revere to mushroom the obtained results are in agreement with results observed by Medany (2004) who reported that feeding hypercho-lesterolemic rats with 3 or 5% dried mushroom effectively lower total cholesterol serum after one week.…”

Section: Chemical Composition Of Beef Patties Fortified With Mushroomsupporting

confidence: 90%

Effect of Feeding on Beef Patties Fortifited With Mushroom on Serum Lipids Profile and Liver Enzymes of Hypercholesterolemic Rats

El-Refai

Elzeiny

Rabo

2011

Journal of Food and Dairy Sciences

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The investigation was carried out to study the effects of feeding hypercholesterolemic rats on 35% beef patties fortified with 0, 4, 8 and 12% oyster dried mushroom on blood serum lipids profile and liver enzymes comparing with feeding on diets containing 8% dried mushroom and 8% defatted soy flour. The results showed that all diets had hypercholesterolemic lowering effect after 30 days comparing to 15 days. Moreover, group fed on 35 % beef patty fortified with 12% dried mushroom had the highest reduction of total cholesterol, triglycerides, LDL, VLDL, total lipids and phospholipids but, it had the highest increasing in HDL comparing to other groups. So, this group had the lowest atherogenic index as CH/HDL-c and LDL/HDL-c comparing to other groups. With respect to liver enzymes GOT and GPT, group fed on 35 % beef patties fortified with 12% dried mushroom had the highest lowering effect comparing to other groups. These results indicated that mushroom had the highest lowering hypercholesterolemic effect. Moreover, the group which fed on 8% defatted soy flour had the same hypercholesterolemic lowering effect of the group which fed on 8% dried mushroom on blood serum lipids profile and liver enzymes. The hypercholesterolemic lowering effect was increased by increasing fortification with dried mushroom in beef patties preparation and also, was increased by increasing feeding time.

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Section: Chemical Composition Of Beef Patties Fortified With Mushroomsupporting

confidence: 90%

Effect of Feeding on Beef Patties Fortifited With Mushroom on Serum Lipids Profile and Liver Enzymes of Hypercholesterolemic Rats

El-Refai

Elzeiny

Rabo

2011

Journal of Food and Dairy Sciences

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“…(14)) on reducing the cholesterol, triglycerides and low density lipoprotein levels in hyperlipidemic rats was recently investigated. [101] …”

Section: 4-dhps With Anti-atherosclerotic Actionmentioning

confidence: 99%

1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets

Carosati¹,

Ioan²,

Micucci³

et al. 2012

CMC

109

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1,4-Dihydropyridines were introduced in the last century for the treatment of coronary diseases. Then medicinal chemists decorated the 1,4-DHP nucleus, the most studied scaffold among L-type calcium channel blockers, achieving diverse activities at several receptors, channels and enzymes. We already described (Ioan et al. Curr. Med. Chem. 2011, 18, 4901-4922) the effects of 1,4-DHPs at ion channels and G-protein coupled receptors. In this paper we continue the analysis of the wide range of biological effects exerted by compounds belonging to this chemical class. In particular, focus is given to the ability of 1,4-DHPs to revert multi drug resistance that, after over 20 years of research, continues to be of great interest. We also describe activities on other targets and the action of 1,4-DHPs against several diseases. Finally, we report and review the interaction of 1,4-DHPs with the hERG channel, transporters and phase I metabolizing enzymes. This work is a starting point for further exploration of the 1,4-DHP core activities on targets, off-targets and antitargets.

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“…Lipoprotein is a complex of triglycerides and cholesteryl esters, surrounded by a hydrophobic phospholipid and protein called apolipoprotein [3]. Hyperlipidemia increase the occurrence of atherosclerosis [4], one of factors that triggering cardiovascular disease, as hypertention; coronary heart [5] and stroke [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of lipid profile and atherogenic index in hyperlipidemic rat (Rattus norvegicus Berkenhout, 1769) that given the methanolic extract of Parijoto (Medinilla speciosa)

Sa’adah

Purwani

Nurhayati

et al. 2017

AIP Conference Proceedings

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Abstract. Diet of high lipids cause hyperlipidemia, which marked by an increase of total cholesterols, triglycerides, LDL-C, and decreasing of HDL-C. Hyperlipidemia lead the occurrence of atherosclerosis, one of factors that trigger cardiovascular disease, as hypertention; coronary heart and stroke. Parijoto (M. speciosa) is endemic plants in Asia with a distribution center in Malaysia, Indonesia and Philippines. Parijoto contain phytochemical components such as flavonoids, saponins and kardenolin. Flavonoid potensial as an antioxidants and can improve the hyperlipidemia condition. This study was aimed to determine lipid profiles and atherogenic index of hyperlipidemic Wistar rats (R. norvegicus Berkenhout, 1769) which given the methanolic extract of Parijoto (M. speciosa). The research was done with pre and post test randomized control group design. Rats were given a mixture of duck yolk and reused cooking oil (1:1) orally as much as 1% of body weight (BW) for 30 days. After hyperlipidemia achieved, rats were divided into 5 group: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of Parijoto (M. speciosa) 500 mg/kg, 1000 mg/kg, and 1500 mg/kg BW. Blood samples were collected when rats in hyperlipidemia conditions and after treatment with the methanolic extract of Parijoto (M. speciosa) for 30 days. The data of total cholesterol, HDLCholesterol, LDL-Cholesterol level, and atherogenic index were analyzed using ANOVA followed by Tukey test at 5% significance level. The result showed that giving of methanolic extract of Parijoto (M. speciosa) in hyperlipidemic rats reduced the total cholesterol, LDL-Cholesterol levels, and increased of HDL-cholesterol levels significantly (p<0.01), so atherogenic index reduced significantly too (p<0.01). Total cholesterol and LDL-Cholesterol levels were positively correlated with the atherogenic index, whereas HDL-cholesterol levels were negatively correlated with the atherogenic index.

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Lipid Lowering Activity ofAnthocephalus indicusRoot in Hyperlipidemic Rats

Cited by 22 publications

References 19 publications

Effect of Feeding on Beef Patties Fortifited With Mushroom on Serum Lipids Profile and Liver Enzymes of Hypercholesterolemic Rats

Effect of Feeding on Beef Patties Fortifited With Mushroom on Serum Lipids Profile and Liver Enzymes of Hypercholesterolemic Rats

1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets

Analysis of lipid profile and atherogenic index in hyperlipidemic rat (Rattus norvegicus Berkenhout, 1769) that given the methanolic extract of Parijoto (Medinilla speciosa)

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