Lipid Intake and Breast Cancer Risk: Is There a Link? A New Focus and Meta-Analysis

Lodi, Massimo; Kiehl, Amélie; Qu, Fei Lin; Gabriele, Victor; Tomasetto, Catherine; Mathelin, Carole

doi:10.4274/ejbh.galenos.2021.2021-11-2

Cited by 5 publications

(5 citation statements)

References 82 publications

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“…14 Findings from meta-analyses for cohort studies have consistently indicated a null association between dietary SFA intake and breast cancer risk, whereas results for case-control studies have suggested potential positive associations, especially in postmenopausal females. [15][16][17] This pattern was in line with findings of serum SFA biomarker levels according to meta-analyses. 15,18 However, more recent observational studies have yielded conflicting conclusions.…”

Section: Introductionsupporting

confidence: 86%

Association between dietary intake of saturated fatty acid subgroups and breast cancer risk

Jiang,

Li,

Hou

et al. 2024

Food Funct.

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Section: Introductionsupporting

confidence: 86%

Association between dietary intake of saturated fatty acid subgroups and breast cancer risk

Jiang,

Li,

Hou

et al. 2024

Food Funct.

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“…They contain at least one monounsaturated fatty acid (MUFA) chain. Higher levels of MUFAs have been reported in breast tumor tissues compared to normal tissues from the same woman [ 38 ], and some, but not others, have suggested associations of MUFAs with breast cancer risk [ 39 ]. PI(18:1/18:1) promotes cell survival and is responsive to diet and stress [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Lipidome of mammographic breast density in premenopausal women

Getz,

Jeon,

Luo

et al. 2023

Breast Cancer Res

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Background High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women. Methods Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St. Louis, MO. Untargeted lipidomic profiling for 982 lipid species was performed at Metabolon (Durham, NC®), and volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV)) was assessed using Volpara 1.5 (Volpara Health®). We performed multivariable linear regression models to investigate the associations of lipid species with MBD and calculated the covariate-adjusted least square mean of MBD by quartiles of lipid species. MBD measures were log10 transformed, and lipid species were standardized. Linear coefficients of MBD were back-transformed and considered significant if the Bonferroni corrected p-value was < 0.05. Results Of the 705 premenopausal women, 72% were non-Hispanic white, and 23% were non-Hispanic black. Mean age, and BMI were 46 years and 30 kg/m2, respectively. Fifty-six lipid species were significantly associated with VPD (52 inversely and 4 positively). The lipid species with positive associations were phosphatidylcholine (PC)(18:1/18:1), lysophosphatidylcholine (LPC)(18:1), lactosylceramide (LCER)(14:0), and phosphatidylinositol (PI)(18:1/18:1). VPD increased across quartiles of PI(18:1/18:1): (Q1 = 7.5%, Q2 = 7.7%, Q3 = 8.4%, Q4 = 9.4%, Bonferroni p-trend = 0.02). The lipid species that were inversely associated with VPD were mostly from the triacylglycerol (N = 43) and diacylglycerol (N = 7) sub-pathways. Lipid species explained some of the variation in VPD. The inclusion of lipid species increased the adjusted R2 from 0.45, for a model that includes known determinants of VPD, to 0.59. Conclusions We report novel lipid species that are associated with MBD in premenopausal women. Studies are needed to validate our results and the translational potential.

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“…Although it suggested a potential inverse association between MUFA consumption and breast cancer, it was not statistically significant [92]. Similarly, other meta-analysis studies also reported that there was no significant positive or negative trend in breast cancer risk with dietary MUFA intake [85,[93][94][95]. A Korean colorectal adenoma study found that there was no significant association with MUFA intake in adults [96].…”

Section: Exogenous Mufa and Cancermentioning

confidence: 96%

“…Although the results of the preclinical SCD1 inhibitor studies are promising, inhibiting SCD1 could disrupt lipid metabolism, potentially affecting normal cellular functions and leading to side effects. In fact, severe adverse effects have been observed in animal studies, such as eye and skin dryness, hair loss and cold-induced hypothermia [ 92 , 93 , 94 , 95 ], which is the primary challenge preventing these inhibitors from being applied to cancer therapy. Therefore, new strategies are needed before SCD1 inhibitors can be fully translated into clinical trials.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives

Bergeron

Lingrand

Mounier

2023

IJMS

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Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the field of cancer due to their potential role in its prevention and treatment. MUFAs can be consumed through the diet or endogenously biosynthesized. Stearoyl-CoA desaturases (SCDs) are key enzymes involved in the endogenous synthesis of MUFAs, and their expression and activity have been found to be increased in various types of cancer. In addition, diets rich in MUFAs have been associated with cancer risk in epidemiological studies for certain types of carcinomas. This review provides an overview of the state-of-the-art literature on the associations between MUFA metabolism and cancer development and progression from human, animal, and cellular studies. We discuss the impact of MUFAs on cancer development, including their effects on cancer cell growth, migration, survival, and cell signaling pathways, to provide new insights on the role of MUFAs in cancer biology.

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Lipid Intake and Breast Cancer Risk: Is There a Link? A New Focus and Meta-Analysis

Cited by 5 publications

References 82 publications

Association between dietary intake of saturated fatty acid subgroups and breast cancer risk

Association between dietary intake of saturated fatty acid subgroups and breast cancer risk

Lipidome of mammographic breast density in premenopausal women

Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives

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