Lipid-induced changes in protein conformation as a means to regulate the immunogenicity of antigens incorporated in tubular immunostimulating complexes

Sanina, N. M.; Vorobieva, Natalia; Novikova, O. D.; Portniagina, O. Yu.; Davydova, L. A.; Shnyrov, Valery L.; Kostetsky, E. Ya.

doi:10.1134/s0006350916030155

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…TI-complexes are able to stimulate immune response both to the membrane [48] and to water-soluble proteins [49]. Their adjuvant effect to antigens depends on the physicochemical properties of MGDG [50] and chemical structure of saponin [49].…”

Section: Adjuvant Familiesmentioning

confidence: 99%

Vaccine Adjuvants Derived from Marine Organisms

Sanina

2019

Biomolecules

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Vaccine adjuvants help to enhance the immunogenicity of weak antigens. The adjuvant effect of certain substances was noted long ago (the 40s of the last century), and since then a large number of adjuvants belonging to different groups of chemicals have been studied. This review presents research data on the nonspecific action of substances originated from marine organisms, their derivatives and complexes, united by the name ‘adjuvants’. There are covered the mechanisms of their action, safety, as well as the practical use of adjuvants derived from marine hydrobionts in medical immunology and veterinary medicine to create modern vaccines that should be non-toxic and efficient. The present review is intended to briefly describe some important achievements in the use of marine resources to solve this important problem.

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Section: Adjuvant Familiesmentioning

confidence: 99%

Vaccine Adjuvants Derived from Marine Organisms

Sanina

2019

Biomolecules

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“…As is known, polar lipid serves as a matrix for the protein antigen into immunostimulating complexes [ 3 ], whereas their saponin part is attributed to exclusively structural role. However, saponins, particularly triterpene glycosides, form molecular complexes with proteins [ 51 ]. The effects of polar lipids and triterpene glycosides isolated from various species of marine macrophytes and invertebrates on the immunogenicity and conformation of model protein antigens (porin from enteropathogen Y. pseudotuberculosis (YOmpF), uncleaved recombinant monomer of influenza virus H1N1 A/California/04/2009 (HA0), and human serum albumin (HSA)) were studied to understand the role of the chemical structure of these compounds in enhancing the effectiveness of vaccines based on the TI-complexes.…”

Section: Effect Of Components Of Ti-complexes On Immunogenicity Ofmentioning

confidence: 99%

“…In detail, results of these studies are described in respective publications [ 50 , 51 ]. As a whole, it was shown that one of ways to achieve the desired immune response is a modulation of not so much fatty acid composition per se as microviscosity of MGDG.…”

Section: Effect Of Components Of Ti-complexes On Immunogenicity Ofmentioning

confidence: 99%

Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems

Sanina

Chopenko

Mazeika

et al. 2017

BioMed Research International

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New generation vaccines, based on isolated antigens, are safer than traditional ones, comprising the whole pathogen. However, major part of purified antigens has weak immunogenicity. Therefore, elaboration of new adjuvants, more effective and safe, is an urgent problem of vaccinology. Tubular immunostimulating complexes (TI-complexes) are a new type of nanoparticulate antigen delivery systems with adjuvant activity. TI-complexes consist of cholesterol and compounds isolated from marine hydrobionts: cucumarioside A2-2 (CDA) from Cucumaria japonica and monogalactosyldiacylglycerol (MGDG) from marine algae or seagrass. These components were selected due to immunomodulatory and other biological activities. Glycolipid MGDG from marine macrophytes comprises a high level of polyunsaturated fatty acids (PUFAs), which demonstrate immunomodulatory properties. CDA is a well-characterized individual compound capable of forming stable complex with cholesterol. Such complexes do not possess hemolytic activity. Ultralow doses of cucumariosides stimulate cell as well as humoral immunity. Therefore, TI-complexes comprising biologically active components turned out to be more effective than the strongest adjuvants: immunostimulating complexes (ISCOMs) and complete Freund's adjuvant. In the present review, we discuss results published in series of our articles on elaboration, qualitative and quantitative composition, ultrastructure, and immunostimulating activity of TI-complexes. The review allows immersion in the history of creating TI-complexes.

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Lipid-induced changes in protein conformation as a means to regulate the immunogenicity of antigens incorporated in tubular immunostimulating complexes

Cited by 2 publications

References 27 publications

Vaccine Adjuvants Derived from Marine Organisms

Vaccine Adjuvants Derived from Marine Organisms

Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems

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