Lipid in Renal Clear Cell Carcinoma: Detection on Opposed-Phase Gradient-Echo MR Images

Outwater, Eric K.; Bhatia, Manoj; Siegelman, Evan S.; Burke, Melissa; Mitchell, Donald G.

doi:10.1016/s0022-5347(01)63636-x

Cited by 32 publications

(49 citation statements)

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“…Intracytoplasmic lipids are depicted with CSI in up to 60% of ccRCCs [36]. For the diagnosis of ccRCC the reported sensitivity and specificity of this finding is 82% and 94%, respectively [17], which differs from the 42% and 100%, values we achieved, respectively.…”

Section: Discussioncontrasting

confidence: 65%

MR classification of renal masses with pathologic correlation

et al. 2007

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To perform a feature analysis of malignant renal tumors evaluated with magnetic resonance (MR) imaging and to investigate the correlation between MR imaging features and histopathological findings. MR examinations in 79 malignant renal masses were retrospectively evaluated, and a feature analysis was performed. Each renal mass was assigned to one of eight categories from a proposed MRI classification system. The sensitivity and specificity of the MRI classification system to predict the histologic subtype and nuclear grade was calculated. Subvoxel fat on chemical shift imaging correlated to clear cell type (p < 0.05); sensitivity = 42%, specificity = 100%. Large size, intratumoral necrosis, retroperitoneal vascular collaterals, and renal vein thrombosis predicted high-grade clear cell type (p < 0.05). Small size, peripheral location, low intratumoral SI on T2-weighted images, and low-level enhancement were associated with low-grade papillary carcinomas (p < 0.05). The sensitivity and specificity of the MRI classification system for diagnosing low grade clear cell, high-grade clear cell, all clear cell, all papillary, and transitional carcinomas were 50% and 94%, 93% and 75%, 92% and 83%, 80% and 94%, and 100% and 99%, respectively. The MRI feature analysis and proposed classification system help predict the histological type and nuclear grade of renal masses.

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Section: Discussioncontrasting

confidence: 65%

MR classification of renal masses with pathologic correlation

et al. 2007

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“…This fi nding was fi rst described in 1997 by Outwater et al for clear cell RCCs 17 and was also reported in papillary RCCs. 18 The former refl ects cytoplasmic fatty granules and the latter fat-laden interstitial histiocytes.…”

Section: Discussionsupporting

confidence: 75%

Magnetic resonance imaging of large chromophobe renal cell carcinomas

et al. 2010

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“…With a usage of chemical-shift gradient-echo MR imaging, fat of lesser amount, or microscopic fat, which does not exhibit negative attenuation value on CT or bright signal on T1-weighted MR images, has become detectable. The lesions reported to have this microscopic fat includes clear-cell RCC [1,4] and angiomyolipoma with minimal fat [10]. The present report adds another entity, granular-cell RCC with foamy histiocytes, to the list of differential diagnoses of renal tumors that contain radiologically detectable microscopic fat.…”

Section: Case Reportmentioning

confidence: 61%

“…Thus, this most common renal malignant tumor was added to a list of differential diagnoses of renal tumors that contain radiologically detectable fat in a broad sense of the word. Angiomyolipoma, classically called renal tumors for which radiologic detection of fat is pathognomonic, usually have macroscopic fat that creates negative attenuation value on computed tomography (CT) or bright signal on conventional T1-weighted MR images [2, 3]; conversely, cytoplasmic fat in clear-cell RCC is microscopic and is detectable only by chemical-shift gradient-echo MR imaging and not by CT or conventional T1-weighted MR images [1,4].We present a case of granular cell RCC that had been shown to have fat on the preoperative chemical-shift gradient-echo MR images and was proven to have fatcontaining foamy histiocytic infiltration in the interstitium of the tumor. …”

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confidence: 99%

Fat detection in granular-cell renal cell carcinoma using chemical-shift gradient-echo MR imaging: another renal tumor that contains fat

et al. 2000

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Preoperative chemical-shift magnetic resonance images in a 56-year-old man suggested the presence of microscopic fat in the tumor. The surgical specimen showed a granular-cell renal cell carcinoma with papillary architecture, associated with abundant fat-containing foamy histiocytes in the interstitium. The radiologist should include this entity in the differential diagnoses of renal tumors that contain microscopic fat.

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Lipid in Renal Clear Cell Carcinoma: Detection on Opposed-Phase Gradient-Echo MR Images

Cited by 32 publications

References 0 publications

MR classification of renal masses with pathologic correlation

MR classification of renal masses with pathologic correlation

Magnetic resonance imaging of large chromophobe renal cell carcinomas

Fat detection in granular-cell renal cell carcinoma using chemical-shift gradient-echo MR imaging: another renal tumor that contains fat

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