Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

Sandstrom, Paul; Tebbey, Paul W.; Cleave, S. Van; Buttke, Thomas M.

doi:10.1016/s0021-9258(17)42178-8

Cited by 189 publications

(11 citation statements)

References 42 publications

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“…Reactive oxygen species, generated in the mitochondria of cells undergoing apoptosis, can initiate a catalytic peroxidation of polyunsaturated lipids [14]. The resulting hydroperoxy fatty acids can induce apoptosis directly in many cell lines [16]. Cells that are normally resistant to polyunsaturated fatty acids can be rendered sensitive to them by expression of a cytochrome that increases intracellular levels of reactive oxygen species [17].…”

Section: Discussionmentioning

confidence: 99%

Apoptosis-inducing natural products found in utero during murine pregnancy

Liberles

Schreiber

2000

Chemistry & Biology

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A family of polyunsaturated fatty acids is shown to be abundant in utero during pregnancy. Members of this family are able to induce cleavage of poly(ADP)ribose polymerase, and ultimately to induce apoptosis, in T-antigen-transformed Jurkat T cells. Free radical scavengers, including phenol and benzyl alcohol, block the apoptosis-inducing properties of these polyunsaturated fatty acids; this is consistent with a lipid peroxidation mechanism involving formation of hydroperoxy fatty acids.

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Section: Discussionmentioning

confidence: 99%

Apoptosis-inducing natural products found in utero during murine pregnancy

Liberles

Schreiber

2000

Chemistry & Biology

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“…A major pathogenetic factor in HIV infection is the induced oxidative stress, which causes apoptosis and a decrease in the number of CD4 + T cells, which may eventually lead to marked immunosuppression [ 89 , 90 ]. Increased oxidative reactions [ 89 ] and higher concentrations of hydrogen peroxide [ 91 ] and MDA [ 92 ], as well as suppression of the antioxidant protection response, with decreased activity of the antioxidant enzymes SOD, GPx, CAT, and thioredoxin, have been found in the plasma, lung mucosa, erythrocytes, and lymphocytes from patients with HIV infection [ 90 , 91 , 93 ].…”

Section: Effects Of La In Viral Infectionmentioning

confidence: 99%

Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections, including COVID-19

et al. 2021

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Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, is thought to play an important pathogenetic role in several diseases, including viral infections. Alpha-lipoic acid (LA) is one of the most-studied and used natural compounds, as it is endowed with a well-defined antioxidant and immunomodulatory profile. Owing to these properties, LA has been tested in several chronic immunoinflammatory conditions, such as diabetic neuropathy and metabolic syndrome. In addition, a pharmacological antiviral profile of LA is emerging, that has attracted attention on the possible use of this compound for the cotreatment of several viral infections. Here, we will review the emerging literature on the potential use of LA in viral infections, including COVID-19.

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“…The deficiency of antioxidants such as catalase (CAT) induces apoptosis via H 2 O 2 in the T cells of the human immunodeficiency virus (HIV) [ 34 ]. Enhanced CAT expression in T cells reduces oxidative stress caused by activated monocytes and granulocytes in patients with chronic inflammatory conditions [ 39 ]. Furthermore, antioxidants such as glutathione peroxidase (GPx) inhibit lipid hydroperoxides in T cells; thus, they can abrogate the antigen-specific T cells by causing ferroptosis [ 40 ].…”

Section: Role Of Exercise-induced Ros In T-cell Activationmentioning

confidence: 99%

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise

Thirupathi

Pinho

2021

Antioxidants

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Nearly all cellular functions depend on redox reactions, including those of immune cells. However, how redox reactions are rearranged to induce an immune response to the entry of pathogens into the host is a complex process. Understanding this scenario will facilitate identification of the roles of specific types of reactive oxygen species (ROS) in the immune system. Although the detrimental effect of ROS could support the innate immune system, the adaptive immune system also requires a low level of ROS in order to stimulate various molecular functions. The requirements and functions of ROS vary in different cells, including immune cells. Thus, it is difficult to understand the specific ROS types and their targeting functions. Incomplete transfer of electrons to a specific target, along with failure of the antioxidant response, could result in oxidative-damage-related diseases, and oxidative damage is a common phenomenon in most immune disorders. Exercise is a noninvasive means of regulating ROS levels and antioxidant responses. Several studies have shown that exercise alone boosts immune functions independent of redox reactions. Here, we summarize how ROS target various signaling pathways of the immune system and its functions, along with the possible role of exercise in interfering with immune system signaling.

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Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

Cited by 189 publications

References 42 publications

Apoptosis-inducing natural products found in utero during murine pregnancy

Apoptosis-inducing natural products found in utero during murine pregnancy

Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections, including COVID-19

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise

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