Lipid disturbances in a two-year follow-up after successful kidney transplantation

Kisielnicka, Ewa; Zdrojewski, Zbigniew; Wróblewska, Małgorzata; Kortas, B.; Rutkowski, Bolesław

doi:10.1016/s0041-1345(00)01256-2

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…Muchos estudios han demostrado que un aumento del índice de masa corporal después del trasplante renal puede afectar desfavorablemente no solo a la función del injerto, sino también al injerto y a la supervivencia del paciente. También hay un mayor riesgo de complicaciones perioperatorias y enfermedades concomitantes (11)(12)(13)(14). Nuestro estudio se ha focalizado fundamentalmente en observar el comportamiento de la función renal al año de ser trasplantado el paciente, centrándonos en el IMC pretrasplante del paciente.…”

Section: Discussionunclassified

Factores predictores de hipertrigliceridemia en pacientes hospitalizados con nutrición parenteral total

et al. 2017

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Introduction: Total parenteral nutrition (TPN) is a kind of nutritional support indicated for patients whose clinical situation makes it impossible to cover their nutritional requirements enterally. Despite the fact that TPN is a safe and effective therapy, some complications have been described. One of the most frequent is hypertriglyceridemia. The etiology of this metabolic complication is complex and multifactorial. Objetive: The aim of this work was to determine risk factors associated with the development of hypertrilgyceridemia in adult inhospital non critical patients who carry TPN for a short term. A secondary aim was to evaluate the effect that a lipid emulsion fortified with omega-3 poliunsaturated fatty acids causes on this metabolic complication. Material and methods: This is an observational retrospective cohort study, in which adult inhospital non critical patients have been included. Only those who needed TPN during more than seven days were included. Hypertriglyceridemia was defined as plasma triglycerides levels higher than 200 mg/dl. The lipid emulsions were composed whether by a combination of 50% long-chain (LCT) and medium-chain (MCT) triglycerides or 40% LCT/50% MCT/10% omega-3. Clinical, nutritonal and biochemical parameters were included. Analitical samples were obtained before starting TPN, and weekly until withdrawal. Multivariate logistic regression analysis was used to identify predictive factors of the appearance of hypertriglyceridemia. Results: One hundred and one patients were included (61.4% male). Thirty-three per cent of them developed hypertriglyceridemia. In the multivariate analysis the independent risk factors associated with the presence of hypertriglyceridemia were the initial plasmatic triglycerides levels, the body mass index (BMI) and an input of glucose in the TPN higher than 3.1 g/kg/day. The infusion of a lipid emulsion fortified with 3-omega fatty acids was associated with a nonsignificant reduction of the risk of appearance of hypertriglyceridemia. Conclusion: The patient’s clinical metabolic situation, as well as the load of carbohydrates in the TPN are essential for the development of the TPN-associated hypertriglyceridemia. The administration of a lipid emulsion fortified with omega-3 fatty acids is safe, even though it was not associated with a signifi cant protective effect over the risk of appearance of this metabolic complication.

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Factores predictores de hipertrigliceridemia en pacientes hospitalizados con nutrición parenteral total

et al. 2017

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“…Our results show that hyperlipidemia is common among stable renal transplant patients, with increases noted for TC, LDL, and HDL. The incidence of hypercholesterolemia peaked within the first year, affecting 20–30% of patients, although the peak increases in TC and LDL may range from 3–18 months (8–11). The sequence of events suggests a causal relationship between hypercholesterolemia and the dose of immunosuppressive agents.…”

Section: Discussionmentioning

confidence: 99%

A long‐term study on hyperlipidemia in stable renal transplant recipients

Tse

Lam

Yip

et al. 2004

Clinical Transplantation

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Renal transplantation is associated with a characteristic pattern of dyslipidemia, with increased TC, LDL and HDL, and a decrease in TG. Patients with pre-existing hypercholesterolemia were at higher risk for post-transplant hypercholesterolemia. Although the incidence of hypercholesterolemia peaks within the first year after transplantation, this remains a long-term complication in a significant proportion of patients on low dose immunosuppressive medications.

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“…Kidney transplant recipients have a long history of chronic renal failure, and consequently, many of them suffer from lipid disorders prior to receiving the transplant . However, lipid metabolism does not return to normal when renal function is recovered after transplant .…”

Section: Resultsmentioning

confidence: 99%

Progression of alterations in lipid metabolism in kidney transplant recipients over 5 years of follow-up

et al. 2014

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Lipid disturbances in a two-year follow-up after successful kidney transplantation

Cited by 10 publications

References 11 publications

Factores predictores de hipertrigliceridemia en pacientes hospitalizados con nutrición parenteral total

Factores predictores de hipertrigliceridemia en pacientes hospitalizados con nutrición parenteral total

A long‐term study on hyperlipidemia in stable renal transplant recipients

Progression of alterations in lipid metabolism in kidney transplant recipients over 5 years of follow-up

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