Lipid discovery enabled by sequence statistics and machine learning
Priya M. Christensen,
Jonathan Martin,
Aparna Uppuluri
et al.
Abstract:Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified thatStreptococcus agalactiaeMprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) from anionic PG, and a novel cationic lipid, lysyl-glucosyl-diacylglycerol (Lys-Glc-DAG), from neutral glycolipid Glc-DAG. This unexpected result prompted us to investigate whether Lys-Glc-DAG occurs in other MprF-containing ba… Show more
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