“…In addition, retrotranslocation or inhibition MODE 0 postulates that BCL2-type proteins inhibit apoptosis by keeping BAX-type proteins inactive through continuous retrotranslocation from the mitochondrial surface into the cytosol [15,16,17,18,19]. These models, however, do not consider an enigmatic property shared by all BCL2-type proteins, which is their ability to promote, rather than inhibit, apoptosis under specific conditions (PRODEATH MODE) [15,20,21,22]. The complex interaction network that orchestrates these proteins’ actions is commonly termed the BCL2 interactome, which constitutes an intricate puzzle yet unresolved (Figure 1).…”