Lipid composition of SV40‐induced transplantable hamster tumor

Abstract

The analysis of the lipid composition of the SV40-induced transplantable hamster tumor has shown that: (a) the total phospholipid content in the tumor is lower than that usually found in normal tissues and similar to that reported for other neoplasms; (b) except for a lower percentage of diphosphatidylglycerol, the phospholipid composition is comparable with that reported for normal tissues; (c) the fatty acid profiles of the various glycerophospholipid classes are characterized by high proportions of oleic acid; and (d) phosphatidylethanolamine contains proportions of alkenyl side chains which are consistent with the amounts of plasmalogenic phospholipids found in other neoplasms.

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

“…It is characterized by high MUFA and decreased levels of SFA and polyunsaturated fatty acid. [18][19][20][21][22][23][24][25] By performing gene-level studies in tumour cells, we identified the central role of SCD in the mechanisms of cell replication. With the use of a small molecule SCD inhibitor, 26 which could be selectively against Δ5 and Δ6 desaturases, or gene interference, studies have shown that the proliferation of cancer cells strictly depends on SCD activity.…”

“…For a long time, abnormal fatty acid composition has been found in in vitro and in vivo experiments. It is characterized by high MUFA and decreased levels of SFA and polyunsaturated fatty acid …”