Lipid composition of rabbit aortic wall following removal of endothelium by balloon catheter.

Myointimal Hyperplasia: Pathogenesis and Implications. 2. Animal Injury Models and Mechanical Factors

“…After balloon catheter injury in rabbits, there is a substantid accumulation of lipid in areas of endothelial regrowth (78,79). This accumulation increases with time, and there is some correlation with the serum lipid concentration and the amount of lipid deposited (79,80).…”

Effect of Oxysterol-Enriched Low-Density Lipoprotein on Endothelial Barrier Function in Culture

“…The major lipid deposited in vascular plaques is choles terol, particularly esterified cholesterol which appears to be principally derived from circulating lipoproteins. There is evidence that intact LDL crosses the morphologically normal endothelium into the subendothelial area [2][3][4][5], and under certain pathological conditions, LDL is the principal source of cholesterol to the vascular tissue [6], Several lines of evidence suggest that the mechanism of atherosclerosis involves dam age to the endothelium, resulting in its re duced effectiveness as a barrier [7,8], It is therefore important to maintain endothelial integrity in order to limit the entry of plasma components, such as cholesterol-rich chylo micron remnants or LDL, into the arterial wall. Evidence suggesting that cholesterol feeding can lead to atherosclerosis was re ported as early as 1913 [9], However, the exact mechanism of the relationship be tween cholesterol and atherosclerosis is still unknown, and it remains unclear whether the etiologic agent is cholesterol itself, or perhaps some other associated factor.…”