clinical work with an early prospect of a feeding back of ideas and procedures.To return briefly to the well-organized system, what has only been mentioned so far in our discussion is the important element of time, for we have essentially depicted static processes, or processes taking place in small fractions of a second (energy transfer). The time element is well appreciated in linked enzymatic reactions, where mathematical expressions may easily be formulated, assuming that the reactions occur freely in solution.We know also, without at present being able to make the same mathematical formulations, that we must add to spatial and chemical specificities the continuous passage of time in order to describe the harmonious integration of the reactions taking place in the smallest unit capable of living normally. This recognition will lead to an understanding of the basis for abnormal function and will help in achieving the ultimate goal of guiding the abnormal into more normal channels. 77 Massachusetts Ave., Cambridge, Mass.