Lipid composition and fluidity of the human immunodeficiency virus.

Abstract

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Effect of Lipid Compositions on Gene Transfer into 293 Cells Using Sendai F/HN-virosomes

“…These differences in hydration also affect lateral packing of the lipid bilayers, another primary factor that governs the interaction and fusion between membranes (Yang et al, 1997). It has been reported that the infectivity of the RNA viruses (such as HIV and Sendai virus) is reduced with the reduction of the cholesterol content in the viral envelope (Citovsky et al, 1986;Aloria et al, 1988), which indirectly supports this speculation. Among the three different virosome types, the ASVE-virosomes exhibited the best gene-transfer Fig.…”

Do lipid rafts mediate virus assembly and pseudotyping?

“…Crucially, the viral membrane is known to be enriched in sphingolipids and cholesterol relative to the plasma membrane (Aloia et al, 1988(Aloia et al, , 1993. There is therefore a significant weight of evidence supporting a role for lipid rafts in the assembly of HIV.…”

Lauric acid inhibits the maturation of vesicular stomatitis virus

“…Furthermore, the triacylglycerols apparently influence membrane fluidity and permeability, parameters which increase with elevated lipid/protein ratio (Aloia et al, 1988). Membrane permeability to certain chemical agents, including anti-cancer drugs and anaesthetics, is impaired by triacylglycerols.…”