Lipid components and fatty acid composition of Iraqi subjects who smoke and consume dairy products

Al-Tamer, Y. Y.; Mahmood, AA

doi:10.1016/s0939-4753(04)80016-4

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…However, the relationship between HCC tumorigenesis and changes in the amounts or composition of circulating plasma lipids has been not fully addressed yet. Moreover, the fatty acid profile in plasma is strongly dependent on the endogenous metabolism of fatty acids and the dietary factor [19,20]. Whether the potential changes in plasma fatty acids of HCC patients are mainly by altered fatty acid metabolisms or by malnutrition is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma

Qiu

Zhang

et al. 2015

Lipids

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Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. In the present study, we aimed to profile the possible changes in plasma phospholipid fatty acid composition of HCC patients, and to identify the fatty acid biomarkers that could distinguish HCC patients from healthy controls. A total of 37 plasma samples from healthy controls and HCC patients were collected and their phospholipid fatty acid profiles were characterized by gas chromatography-mass spectrometry followed by multivariate statistical analysis. Twenty-five fatty acids were identified and quantified, their proportions varied greatly between two groups, suggesting each group has its own fatty acid pattern. Orthogonal partial least squares discriminant analysis in terms of fatty acid profiles showed that HCC patients could be clearly distinguished from healthy controls. More importantly, linoleic acid (18:2n-6), oleic acid (18:1n-9), arachidonic acid (20:4n-6) and palmitic acid (16:0) were identified as the potential fatty acid biomarkers of HCC patients. Additionally, to further identify the major cause of the abnormality of plasma fatty acid profile, fatty acid distributions of cancerous tissue and its surrounding tissue from 42 HCC patients were also examined. Due to have similar variation trend of major fatty acid biomarkers, linoleic acid (18:2n-6), oleic acid (18:1n-9), abnormalities in plasma phospholipid fatty acid profiles of HCC patients may be mainly attributed to the alternation of intrinsic fatty acid metabolism caused by cancer per se, but not to the differences in dietary factors.

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Section: Introductionmentioning

confidence: 99%

Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma

Qiu

Zhang

et al. 2015

Lipids

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“…On the other hand, essentialfatty acid (EFAs) deficiency leads to increase cholesterol synthesis by affecting the activity of HMG-CoA reductase (cholesterol rate-limiting enzyme) (5,19) . Concerning the sebum PLs, they exhibited a higher level in the consumer group, which reflects the fact that high-fat diets, including dairy products, tend to increase PLs (23,24) . This seems to be in harmony with what Mahmood (2002) states about the serum PLs of subjects who consume dairy products.…”

Section: Discussion a Sebum Lipid Componentsmentioning

confidence: 96%

“…The Table shows a lower percentage of MUFAs for CE, PLs and, to some extent, TGs although dairyproduct lipid contains a high proportion of oleic acid (26,27) . The negative correlation may be attributed to either the consumption of other sources of the diet by the two groups or to the enzymatic competition for desaturases and elongases during the endogenous synthesis (24) . Generally, when analyzing the FA composition of tissue samples to estimate the FA composition of the diet, strong correlations have been found between EFAs and the estimated dietary intake.…”

Section: B Sebum Fatty-acid Compositionmentioning

confidence: 99%

Effects of dairy-products' consumption on sebum lipids and fatty acids

Mahmood¹,

Al-Tamer²

2009

Ann Coll Med Mosul

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Objectives:To investigate the effect of intake of dairy-products on the sebum lipid components and fatty-acid composition. Patients and Methods: Sebaceous cysts were obtained, by simple surgery, from the scalp, face and neck of 21 men (aged 25-50 y) and divided into two groups. The first group included 11 cysts for subjects consuming dairy products and the second group included 10 cysts for subjects not consuming dairy products. Simple lipids, phospholipids (PLs), triglycerides (TGs), cholesterol (C), cholesterol ester (CE) and fatty acids (FAs) were removed by organic solvents extraction. The sebum lipid components, TGs and C, were determined enzymatically and PLs were determined using a colorimetric method based on the formation of a phosphomolybdate complex. Lipid components were separated by TLC. The separated components were hydrolyzed and their FAs were esterified by super dried-acidified methanol. Fatty-acid methyl esters were identified by capillary gas chromatography. Results: Compared to the non-consumers group, the consumers group exhibited a significant increase in lipid contents, viz, PLs and C. Concerning the FA composition of CE, PLs and TGs, n 6polyunsaturated FAs showed a higher percentage, viz. C 18:2 n 6 and C 9 ,t 11 CLA, while n 3 -polysaturated FAs showed a significant decrease, viz. C 20:5 n 3 . Conclusion: Consumption of dairy products affects the lipid content and the FA composition of sebum and C9,t11 Conjugated Linoleic Acid could be used as a marker for intake of dairy-product lipid.

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“…But the results of (TG) and (VLDL-C) in gallstone patients showed unsignificant results compared with control group as show in table (1). wherease the results showed that a significant increase in (PL) this increases may be due to action of hepatic lipases which lead to abnormality metabolism of lipids specially phospholipids (17) and may cause of smoking which the import factor of increase (PL) in serum (18).…”

Section: -Lipid Fractionsmentioning

confidence: 99%

Analysis of Blood Serum and Gallstone Lipids Composition of Gallstone Patients

Jasim¹

2011

J.Edu.Sci.

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Lipid components and fatty acid composition of Iraqi subjects who smoke and consume dairy products

Cited by 5 publications

References 8 publications

Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma

Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma

Effects of dairy-products' consumption on sebum lipids and fatty acids

Analysis of Blood Serum and Gallstone Lipids Composition of Gallstone Patients

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