Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides

Bao, Peng; Paterson, Daniel A.; Harrison, Patrick L.; Miller, Keith; Peyman, Sally A.; Jones, John C.; Sandoe, Jonathan; Evans, Stephen D.; Bushby, Richard J.; Gleeson, Helen F.

doi:10.1039/c8lc01291a

Cited by 70 publications

(77 citation statements)

References 42 publications

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“…[ 15–21 ] Regarding biosensors, the concept involves either the imaging of targeted species displayed at solid surfaces, or sensing at LC/aqueous interfaces (LC thin films or droplets). So far, LC‐based biosensors have been reported to detect a wide range of biomolecules such as glucose, [ 22 ] cholesterol, [ 23 ] lipids, [ 24 ] antimicrobial peptides, [ 25 ] proteins, [ 26,27 ] antigens, [ 28 ] pathogen DNA, [ 29 ] viruses, [ 30 ] bacteria, [ 31 ] or mammalian cells. [ 32,33 ] Nonetheless, the exploitation of LCs in biosensing devices has already been reviewed by other authors [ 16,19 ] and is outside the scope of this work.…”

Section: Introductionmentioning

confidence: 99%

Seeing the Unseen: The Role of Liquid Crystals in Gas‐Sensing Technologies

Esteves

Ramou

Porteira

et al. 2020

Advanced Optical Materials

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Fast, real‐time detection of gases and volatile organic compounds (VOCs) is an emerging research field relevant to most aspects of modern society, from households to health facilities, industrial units, and military environments. Sensor features such as high sensitivity, selectivity, fast response, and low energy consumption are essential. Liquid crystal (LC)‐based sensors fulfill these requirements due to their chemical diversity, inherent self‐assembly potential, and reversible molecular order, resulting in tunable stimuli‐responsive soft materials. Sensing platforms utilizing thermotropic uniaxial systems—nematic and smectic—that exploit not only interfacial phenomena, but also changes in the LC bulk, are demonstrated. Special focus is given to the different interaction mechanisms and tuned selectivity toward gas and VOC analytes. Furthermore, the different experimental methods used to transduce the presence of chemical analytes into macroscopic signals are discussed and detailed examples are provided. Future perspectives and trends in the field, in particular the opportunities for LC‐based advanced materials in artificial olfaction, are also discussed.

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Section: Introductionmentioning

confidence: 99%

Seeing the Unseen: The Role of Liquid Crystals in Gas‐Sensing Technologies

Esteves

Ramou

Porteira

et al. 2020

Advanced Optical Materials

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“…Other possibilities that also yet remain visions of their inventors include the self-assembly of colloidal and emulsion systems with potential applications for optical computers [9][10][11] and biological sensors. [12,13] Meeting such potential, however, will require particles and media that are significantly more functional than the simple system used for e-paper. One of the more promising approaches is that of nematic liquid crystal dispersions.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, there has been a wealth of activity in using nematic liquid crystals as hosts for particulate dispersions due to their optical and electrically controllable and anisotropic nature. [12][13][14][15][16][17][18][19][20][21][22][23] NLCs are ordered fluids, in which the constituent anisotropic molecules exhibit long range orientational order. [24] In such a system, the molecules have no positional order but share a common pointing direction, described by headless unit pseudovector n, called the director.…”

Section: Introductionmentioning

confidence: 99%

Electrically Driven Rotation and Nonreciprocal Motion of Microparticles in Nematic Liquid Crystals

Solodkov

Saxena

Jones

2020

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Dispersion of microparticles in nematic liquid crystals offers a novel means for controlling both their orientation and position through the combination of topology and external stimuli. Here, cuboidal and triangular prism shaped microparticles in parallel plate capacitor cells filled with a nematic liquid crystal are studied. Experimental observations are compared with numerical simulations to show that the optimal orientation of the particles is determined by their aspect rations, the relative separation gap of their containers and the applied voltage. It is observed that in systems that allow unrestricted particle rotation, the long axes of the particles are able to fully align themselves with the external electric field. However, when particle rotation is geometrically restricted, it is found that increasing the voltage past a critical value causes the short axis of the particle to realign with the electric field due to anchoring breaking. It is shown that symmetry of the particles then plays a key role in their dynamics following the removal of the electric field, allowing the triangular prisms to travel perpendicular to the applied electric field, whereas only rotation is possible for the cuboidal particles.

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“…[15][16][17][18][19] LCs provide the foundation for mature electronic applications 20 as well as for putative applications as chemical sensors, bacterial detectors, and so forth. 21,22 In such multi-component systems, the LC behaviour depends on system composition, the presence of emulsions, temperature and other thermodynamic conditions. 23 When NPs and LCs are simultaneously present, interesting features emerge, in which NPs and LCs guide each other's self-assembly, yielding sometimes unexpected results.…”

Section: Introductionmentioning

confidence: 99%