Lipid-coated biodegradable particles as “synthetic pathogens” for vaccine engineering

Core–shell‐type polymer–lipid nanoparticles for the transdermal delivery of daidzein

“…Core-shell polymer-lipid nanoparticles are applied in various drug delivery applications, such as being desirable adjuvants for vaccine delivery [7], loading docetaxel to treat cancer [8] and providing a hybrid nanoparticle system for siRNA delivery [9]. Core-shell polymer-lipid nanoparticles are a promising platform for drug delivery because they can deliver multiple drugs, increase drug encapsulation, control drug release rates and exert therapeutic effects [8][9][10].…”

Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer

“…Besides passive targeting of CSLPHNPs based on particle size, they can be conjugated with appropriate targeting ligands such as aptamers (134), folic acid (97,135), transferrin (136), anticarcinoembryonic antigen half-antibody (94), single-chain tumor necrosis factor (121) to deliver NPs at the target tissues for treating cancers. Smaller than 100-nm particles (similar to virus-like architecture) are promising for intracellular drug targeting and vaccine adjuvants (137).…”

“…Antigens adsorbed or covalently coupled onto the surface of pre-synthesized CSLPHNPs could be viable strategies for vaccine delivery (105,198). "Synthetic pathogens", which are surfacemodified biodegradable CSLPHNPs, can be used to imitate structural features of pathogens for designing vaccine adjuvants (137). In this context, polymeric core nanoparticles (e.g.…”