Abstract:Eukaryotic cells are composed of a variety of organelles. Their coordination plays crucial roles in cellular homeostasis and organism longevity and is mediated by proteins with the ability to transport between different organelles. In Caenorhabditis elegans, LBP-8 is a pro-longevity lipid chaperone that can localize to both lysosomes and the nucleus. Here we profiled LBP-8's binding partners using immunoprecipitation and mass spectrometry. From the 45 identified candidates, we discovered four nuclear factors t… Show more
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