Lipid changes in extrapulmonary organs and serum of rats after chronic exposure to ambient fine particulate matter

Lin, Ching-Fuh; Chen, Wenling; Chen, Ting Zhen; Lee, Sheng Han; Liang, Hao; Chou, Charles C.‐K.; Tang, Chuan Ho; Cheng, Tsun‐Jen

doi:10.1016/j.scitotenv.2021.147018

Cited by 7 publications

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, changes in the lipid metabolism of zebrafish tissues and cells have been connected to various disease processes . Given that PC is the most abundant constituent of cellular membranes in animals and humans, membrane integrity, oxidative stress, and cell signaling in AgNS-exposed zebrafish can be greatly influenced when PC levels decrease . Previous studies demonstrated that nanosilvers caused changes in the fatty acid profile, lipid peroxidation, and membrane fluidity of cell membranes in common carp gills and disrupted cellular signaling functions to induce cell death in zebrafish …”

Section: Resultsmentioning

confidence: 99%

“…34 Given that PC is the most abundant constituent of cellular membranes in animals and humans, 64 membrane integrity, oxidative stress, and cell signaling in AgNS-exposed zebrafish can be greatly influenced when PC levels decrease. 65 Previous studies demonstrated that nanosilvers caused changes in the fatty acid profile, lipid peroxidation, and membrane fluidity of cell membranes in common carp gills 57 and disrupted cellular signaling functions to induce cell death in zebrafish. 66 Additionally, we found that alterations in several lipids did not occur in a single organ when exposed to nanosilvers but rather in two organs (e.g., gill and liver, gill and intestine, liver and intestine) or three other organs (gill, liver, and intestine) (Figure S7).…”

Section: Environmentalmentioning

confidence: 99%

See 1 more Smart Citation

Mass Spectrometry Imaging Reveals the Morphology-Dependent Toxicological Effects of Nanosilvers on Multiple Organs of Adult Zebrafish (Danio rerio)

Xie,

Li,

Chen

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Nanosilvers with multifarious morphologies have been extensively used in many fields, but their morphology-dependent toxicity toward nontarget aquatic organisms remains largely unclear. Herein, we used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the toxicological effects of silver nanomaterials with various morphologies on spatially resolved lipid profiles within multiple organs in adult zebrafish, especially for the gill, liver, and intestine. Integrated with histopathology, enzyme activity, accumulated Ag contents and amounts, as well as MSI results, we found that nanosilvers exhibit morphology-dependent nanotoxicity by disrupting lipid levels and producing oxidative stress. Silver nanospheres (AgNSs) had the highest toxicity toward adult zebrafish, whereas silver nanoflakes (AgNFs) exhibited greater toxicity than silver nanowires (AgNWs). Levels of differential phospholipids, such as PC, PE, PI, and PS, were associated with nanosilver morphology. Notably, we found that AgNSs induced greater toxicity in multiple organs, such as the brain, gill, and liver, while AgNWs and AgNFs caused greater toxicity in the intestine than AgNSs. Lipid functional disturbance and oxidative stress further caused inflammation and membrane damage after exposure to nanosilvers, especially with respect to sphere morphology. Taken together, these findings will contribute to clarifying the toxicological effects and mechanisms of different morphologies of nanosilvers in adult zebrafish.

show abstract