Lipid Biomarkers in Acute Myocardial Infarction Before and After Percutaneous Coronary Intervention by Lipidomics Analysis

Lin, Feng; Yang, Jianzhou; Liu, Wennan; Wang, Qing; Wang, Huijie; Shi, Le; Fu, Li-Yan; Chen, Nansheng; Wang, Baohe; Tian, Lei

doi:10.12659/msm.908732

Cited by 20 publications

(17 citation statements)

References 50 publications

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“…Traditional lipid factors, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) have been widely used as predictors in acute coronary syndrome [9, 10]. Apolipoprotein A1 (ApoA1), the main protein component of HDL-C in the plasma has functions of protecting against atherosclerosis and cardiovascular disease, meanwhile it could also promote cellular cholesterol efflux and cholesterol transportation from peripheral tissues to the liver [11].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Chen

Yang

et al. 2019

Lipids Health Dis

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Background The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods 311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions. Results The Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score ( r = − 0.119, P = 0.044 and r = − 0.182, P = 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score ( β = − 0.151, P = 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively ( P = 0.001). Conclusions The ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Chen

Yang

et al. 2019

Lipids Health Dis

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“…In the serum of patients who underwent myocardial infarction, 16 fatty acids were isolated as biomarkers that enable early monitoring and have diagnostic value [ 47 ]. After acute cardiac ischemia, serum levels of these fatty acids increase, indicating inhibition of their beta-oxidation (it is the dominant source of ATP in the myocardium under normal conditions).…”

Section: Lipidomicsmentioning

confidence: 99%

Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia—Reperfusion Injury

Todorović

Đurašević

Stojković

et al. 2021

IJMS

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Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain damage until cell death. The critical event in such a series of harmful events in the cell is the unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional insight into the pathogenesis of ischemia/reperfusion (I/R) disorders and reveals new targets for drug action. The profile of changes in the composition of fatty acids in the cell, as well as the time course of these changes, indicate both the mechanism of damage and new therapeutic possibilities. A therapeutic approach to reperfusion lipotoxicity involves attenuation of fatty acids overload, i.e., their transport to adipose tissue and/or inhibition of the adverse effects of fatty acids on cell damage and death. The latter option involves using PPAR agonists and drugs that modulate the transport of fatty acids via carnitine into the interior of the mitochondria or the redirection of long-chain fatty acids to peroxisomes.

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“…Lipids are involved in CVD and AMI, not only as ROS targets but also due to the adaptation of lipid metabolism in these processes. Lipidomic analysis performed in plasma revealed an increase in free fatty acid levels at the onset of AMI [ 21 , 22 ] and in oxidised low-density lipoprotein [ 23 ]. Omega-3 and stearic acids were inversely correlated with the risk of AMI, while arachidonic acid and oxylipins were positively correlated [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model

Montero-Bullón

Aveiro

Melo

et al. 2021

Biochemistry and Biophysics Reports

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Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage of blood flow causes myocardial ischemia and cell death. Reperfusion after ischemia has paradoxical effects and may exacerbate the myocardial injury, a process known as ischemic reperfusion injury. In this work we evaluated the lipidome of isolated rat hearts, maintained in controlled perfusion (CT), undergoing global ischemia (ISC) or ischemia followed by reperfusion (IR). 153 polar lipid levels were significantly different between conditions. 48 features had q < 0.001 and included 8 phosphatidylcholines and 4 lysophospholipids, which were lower in ISC compared to CT, and even lower in the IR group, suggesting that IR induces more profound changes than ISC. We observed that the levels of 16 alkyl acyl phospholipids were significantly altered during ISC and IR. Overall, these data indicate that myocardial lipid remodelling and possibly damage occurs to a greater extent during reperfusion. The adaptation of cardiac lipidome during ISC and IR described is consistent with the presence of oxidative damage and may reflect the impact of AMI on the lipidome at the cellular level and provide new insights into the role of lipids in the pathophysiology of acute myocardial ischemia/reperfusion injury.

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Lipid Biomarkers in Acute Myocardial Infarction Before and After Percutaneous Coronary Intervention by Lipidomics Analysis

Cited by 20 publications

References 50 publications

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia—Reperfusion Injury

Cardiac phospholipidome is altered during ischemia and reperfusion in an ex vivo rat model

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