Lipid‐Based Pharmaceutical Nanocarriers for Imaging Applications

Elbayoumi, Tamer; Torchilin, Vladimir P.

doi:10.1002/9781118873151.ch3

Cited by 3 publications

(6 citation statements)

References 140 publications

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“…However, in all these techniques, aqueous medium is a most efficient pathway to obtain iron magnetic NPs. It has been demonstrated the particle size as well as the polydispersity of the NPs could be tailored by changing the associated factors such as Fe 2+/ Fe 3+ ratio, 24 , 28 base (NaOH, ammonium hydroxide, and CH 3 NH 2 ), and ionic strength (N(CH 3 ) 4+ , CH 3 NH 3+ , NH 4+ , Na + , Li + , and K + ). 4 Some other factors also influence on the size of the NPs, 29 eg, an increase in mixing rate, temperature, inlet of nitrogen gas, agitation, pH, and reactants ratio.…”

Section: Methods For the Preparation Of Iron Npsmentioning

confidence: 99%

“…The reaction of Fe(II) salt, in aqueous solution, to a base in the presence of mild oxidant synthesizes spherical NP of 30–100 nm. 24 , 28 The factors on which the phase and size of the particles depend are the concentration of cations, the presence of counter ions, and pH of the solution. Change in pH and ionic strength play a vital role in controlling the mean size of the particles (from 15 nm to 2 nm).…”

Section: Brief Techniques For the Synthesis Of Magnetic Npsmentioning

confidence: 99%

“…After the modulation of the studied parameters, it is possible to obtain particles with a size ranging from 16.6 nm to 4.2 nm. 7 , 28 …”

Section: Brief Techniques For the Synthesis Of Magnetic Npsmentioning

confidence: 99%

“… 9 The synthesis of iron oxide NPs coated with biological molecules, eg, gluconic acid, lactobionic acid, or polyacrylic acid, through the most effective method of coprecipitation as compared to organic solvent heating method and/or polyol method are reported in the literature. 28 , 82 NPs of such types have narrow size distribution and are highly water soluble. They have great potential in numerous biomedical applications such as tissue engineering because of the biological coatings such as liposome coating.…”

Section: Surface Coatings Of Npsmentioning

confidence: 99%

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Synthesis, characterization, applications, and challenges of iron oxide nanoparticles

Ali¹,

Zafar²,

Zia³

et al. 2016

NSA

1,211

549

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Abstract:Recently, iron oxide nanoparticles (NPs) have attracted much consideration due to their unique properties, such as superparamagnetism, surface-to-volume ratio, greater surface area, and easy separation methodology. Various physical, chemical, and biological methods have been adopted to synthesize magnetic NPs with suitable surface chemistry. This review summarizes the methods for the preparation of iron oxide NPs, size and morphology control, and magnetic properties with recent bioengineering, commercial, and industrial applications. Iron oxides exhibit great potential in the fields of life sciences such as biomedicine, agriculture, and environment. Nontoxic conduct and biocompatible applications of magnetic NPs can be enriched further by special surface coating with organic or inorganic molecules, including surfactants, drugs, proteins, starches, enzymes, antibodies, nucleotides, nonionic detergents, and polyelectrolytes. Magnetic NPs can also be directed to an organ, tissue, or tumor using an external magnetic field for hyperthermic treatment of patients. Keeping in mind the current interest in iron NPs, this review is designed to report recent information from synthesis to characterization, and applications of iron NPs.

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Section: Methods For the Preparation Of Iron Npsmentioning

confidence: 99%

Section: Brief Techniques For the Synthesis Of Magnetic Npsmentioning

confidence: 99%

“…After the modulation of the studied parameters, it is possible to obtain particles with a size ranging from 16.6 nm to 4.2 nm. 7 , 28 …”

Section: Brief Techniques For the Synthesis Of Magnetic Npsmentioning

confidence: 99%

Section: Surface Coatings Of Npsmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, characterization, applications, and challenges of iron oxide nanoparticles

Ali¹,

Zafar²,

Zia³

et al. 2016

NSA

1,211

549

View full text Add to dashboard Cite

show abstract

“…Gd-rhodamine liposomes (enabling dual imaging modalities; Gd-MRI; and rhodamine-fluorescent) were injected IV (300 μl); 24 and 48 h after the injection mice were scanned by MRI, then the lungs were resected and analyzed histologically to visualize the exact tissue deposition of the liposomes [68].…”

Section: Mr Imagingmentioning

confidence: 99%

Nanoparticles target early-stage breast cancer metastasisin vivo

et al. 2017

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Despite advances in cancer therapy, treating cancer after it has metastasized remains an unmet clinical challenge. In this study we demonstrate that 100 nm liposomes target triple-negative murine breast-cancer metastases post intravenous administration. Metastatic breast cancer was induced in BALB/c mice either experimentally, by a tail vein injection of 4T1 cells, or spontaneously, after implanting a primary tumor xenograft. To track their biodistribution in vivo the liposomes were labeled with multi-modal diagnostic agents, including indocyanine green and rhodamine for whole-animal fluorescent imaging, gadolinium for magnetic resonance imaging (MRI), and europium for a quantitative biodistribution analysis. The accumulation of liposomes in the metastases peaked at 24 h post the intravenous administration, similar to the time they peaked in the primary tumor. The efficiency of liposomal targeting to the metastatic tissue exceeded that of a non-liposomal agent by 4.5-fold. Liposomes were detected at very early stages in the metastatic progression, including metastatic lesions smaller than 2 mm in diameter. Surprisingly, while nanoparticles target breast cancer metastasis, they may also be found in elevated levels in the pre-metastatic niche, several days before metastases are visualized by MRI or histologically in the tissue. This study highlights the promise of diagnostic and therapeutic nanoparticles for treating metastatic cancer, possibly even for preventing the onset of the metastatic dissemination by targeting the pre-metastatic niche.

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