Lipid‐based Nutrient Supplements Do Not Affect Gut <i>Bifidobacterium</i> Microbiota in Malawian Infants

Aakko, Juhani; Grześkowiak, Łukasz; Asukas, Tiia; Päivänsäde, Eerika; Lehto, Kirsi‐Maarit; Fan, Yue‐Mei; Mangani, Charles; Maleta, Kenneth; Ashorn, Per; Salminen, Seppo

doi:10.1097/mpg.0000000000001333

Cited by 13 publications

(16 citation statements)

References 46 publications

(72 reference statements)

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“…The evidence for a causal role of the gut microbiota in delayed growth is increasing ( 5 ). An immature and less diverse microbiota, which is often present in children with delayed growth, may reduce or prevent the success of nutritional interventions aiming to promote growth ( 8 ). Therefore, in recent decades the scientific focus has shifted to interventions targeting the gut microbiota such as probiotics, prebiotics, and synbiotics because they may have the potential to address stunting effectively ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota–Targeted Nutritional Interventions Improving Child Growth in Low- and Middle-Income Countries: A Systematic Review

Heuven

Pyle

Greyling

et al. 2021

Current Developments in Nutrition

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The objective of this systematic literature review was to evaluate the efficacy of probiotic, prebiotic, and synbiotic interventions compared to control on improving growth outcomes of children living in low-and middle-income countries (LMICs). Probiotics had a beneficial effect on at least one of the growth outcomes in five out of the eleven included studies. Of these, three studies were conducted in undernourished children, one in healthy children, and one in children without a described health status. No effect of prebiotics on the growth outcomes was seen in the four included studies. Synbiotics had a beneficial effect on growth outcomes in three out of four studies. While a limited number of studies with high heterogeneity indicate that probiotics and synbiotics may have the potential to improve the growth of both undernourished and healthy children living in LMIC, more research is needed to confirm the observed effects. The study was registered at the international prospective register of systematic reviews (PROSPERO, reg. no. CRD42020212998).

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota–Targeted Nutritional Interventions Improving Child Growth in Low- and Middle-Income Countries: A Systematic Review

Heuven

Pyle

Greyling

et al. 2021

Current Developments in Nutrition

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“…Table 5 shows the characteristics of “microbiome complementary feed” studies. Seven “microbiome complementary feeds” studies [ [51] , [52] , [53] , [54] , [55] , [56] , [57] ] met the inclusion criteria and were included for analysis. Out of these, 5 studies [ [52] , [53] , [54] , 56 , 57 ] were conducted among healthy children, whereas 2 [ 51 , 55 ] were among children with undernutrition.…”

Section: Resultsmentioning

confidence: 99%

Gut Microbiome-Targeted Nutrition Interventions and Growth among Children in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Addae,

Apprey,

Kwarteng

2024

Current Developments in Nutrition

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“…Specifically, lower counts of Bifidobacterium infantis, Bifidobacterium lactis and Bibidobacterium longum were found, coupled with higher counts of total bacterial, Bifidobacterium genus and Bifidobacterium catenulatum. Moreover, Staphylococcus aureus decreased over time in the studied infants [37]. Subsequently, this intervention was extended up to 12 months.…”

Section: Intervention Studies Performed In Infants and Toddlersmentioning

confidence: 90%

“…The recommended iron intakes for women of fertile age ranges from 14.8 to 20 mg/d depending on the country [36]. In Spain, Daily Recommended Intakes (DRI) of iron for women of childbearing age is 18 mg/day and 10 mg/day for men and postmenopausal women [37]. Dietary surveys conducted in European countries described that large segment of children and women have dietary iron intakes below these recommendations.…”

Section: Introductionmentioning

confidence: 99%

Iron Supplementation at the Crossroads of Nutrition and Gut Microbiota: The State of the Art

et al. 2022

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Gut microbiota has received significant attention owing to its decisive role in human health and disease. Diet exerts a significant influence on the variety and number of bacteria residing in the intestinal epithelium. On the other hand, as iron is a key micronutrient for blood formation and oxygen supply, its deficiency is highly prevalent worldwide. In fact, it is the most common cause of anemia and thus, iron supplementation is widespread. However, there is concern due to some potential risks linked to iron supplementation. Therefore, we have reviewed the available evidence of the effects that iron supplementation exerts on the gut microbiota as well as its potential benefits and risks. The compiled information suggests that iron supplementation is potentially harmful for gut microbiota. Therefore, it should be performed with caution, and by principle, recommended only to individuals with proven iron deficiency or iron-deficiency anemia to avoid potential adverse effects. In any case, large and long-term population studies are urgently needed to confirm or refute these results, mainly focused on vulnerable populations.

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Lipid‐based Nutrient Supplements Do Not Affect Gut Bifidobacterium Microbiota in Malawian Infants

Abstract: The dietary supplementation did not have an effect on the Bifidobacterium and S aureus microbiota composition of the study infants. The fecal bifidobacterial diversity of the infants, however, changed toward a more adult-like microbiota profile within the observed time.

Cited by 13 publications

References 46 publications

Gut Microbiota–Targeted Nutritional Interventions Improving Child Growth in Low- and Middle-Income Countries: A Systematic Review

Gut Microbiota–Targeted Nutritional Interventions Improving Child Growth in Low- and Middle-Income Countries: A Systematic Review

Gut Microbiome-Targeted Nutrition Interventions and Growth among Children in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Iron Supplementation at the Crossroads of Nutrition and Gut Microbiota: The State of the Art

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