Lipid-Based Nanosystem As Intelligent Carriers for Versatile Drug Delivery Applications

Abstract

: The contemporary drug discovery research shows that most of the drug candidates are highly potent, but showing poor aqueous solubility leads a variety of challenges for formulation scientists to develop a suitable formulation to improve the systemic bioavailability of such drugs. Lipid-based nanocarriers act as a major and most projecting approach overcoming the limitations which affect several physiochemical properties of drug such as the solubility, partition coefficient and bioavailability or absorption. This also fulfills a variety of product requirements and helps to overcome several limitations as decided by symptoms of the disease, various routes of administration of drug, price concern, increasing strength of product, noxious or harmful effect of drug, and dose efficacy. The lipidic nanosystem formulates aqueous drug in lipid base and is also a commercially feasible approach for the formulation of different dosage forms meant for topical or transdermal, oral, ocular, pulmonary, and parenteral delivery. This review provides a brief on lipid-based drug delivery nanocarrier and the mechanisms by which lipids and lipidic excipients improve the oral absorption of drugs with poor aqueous solubility and also provide a viewpoint on the promising applications of lipidic nanoparticulate systems.

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

“…Apart from polymer conjugated systems, lipid-based systems have also shown significant potential in the production of regenerative medicines for cancer therapy [ 319 ] and other disorders or diseases [ 320 ]. In a study, researchers developed stimuli-responsive and chitosan-based by-functional polymerized nanocarriers to act as a potential material for drug delivery and tissue engineering applications.…”

Systematic Development of Solid Lipid Nanoparticles of Abiraterone Acetate with Improved Oral Bioavailability and Anticancer Activity for Prostate Carcinoma Treatment

“… 13 , 14 SLNs possess various advantages over polymeric nanoparticles like high drug loading capacity, surface functionalization ability, ease of manufacturing, and scale-up characteristics. 15 , 16 Lipid nanoparticles are reported to be suitable for the stabilization of pharmaceuticals, exhibiting polymorphism problems. A variety of options are available in lipid selection for designing SLNs capable of addressing the drug delivery challenges.…”

“…The lipid nanoparticles attempted to overcome the biopharmaceutical challenges of abiraterone acetate followed by selective absorption of the drug through the oral route, thus improving the anticancer activity. 19 Further, surface functionalization of SLNs with ligands, peptides, antigens, and so forth also helps them in achieving tumor-specific drug targeting. For attaining the best therapeutic performance, systematic optimization of the nanopharmaceutical drug products is essential.…”

Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches

“…However, despite the various advantages, many of these nanocarriers innately face drug delivery-related issues such as normal tissue toxicity, non-specific delivery, and the risk of unintended drug release (Mishra et al 2019;Li et al 2021). Among all the nanocarriers explored for treating GBM, lipid-based NPs are preferred owing to the biocompatibility of the products used, such as lipids, triglycerides, fatty acids, and waxes; enhanced penetrability due to desired particle sizes varying between 50 and 300 nm; higher stability due to the advent of a combination of emulsifiers; and increased permeability (Aparicio-Blanco and Torres-Suarez 2015; Karim et al 2016;Barkat et al 2020). In addition, these nanocarriers can transport bioactive compounds such as nucleic acids and enzymes to target the tumor site.…”