Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy

Pund, Swati; Thakur, R. S.; More, Umesh; Joshi, Amita

doi:10.1016/j.colsurfb.2014.05.016

Cited by 55 publications

(19 citation statements)

References 32 publications

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“…A spontaneous emulsification method was used to generate the nanoformulations with the aid of mild agitation at room temperature based on Pund et al [24] with some modifications. The mnemonic system was applied to name the formulations, and each has also been defined in Table 1.…”

Section: Formulation Of Nanoemulsionsmentioning

confidence: 99%

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

et al. 2020

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Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and characterized and evaluated for their capabilities to penetrate/permeate the skin. In nanoformulations, the thermodynamic activity of the RSV penetration into/permeation through the skin was correlated with the thermodynamic activity of the RSV in the formulations. When terpenes were incorporated into the nanoformulations, the permeation of RSV through the skin increased and correlated with an increasing lipophilicity of the terpene. The nanoemulsion containing eugenol showed the highest RSV penetration into the stratum corneum (SC) and the epidermis-dermis-follicle region, whereas the limonene containing nanoemulsion had the highest RSV permeation through the skin (the enhancement ratios, compared to a saturated solution of RSV, were (i) 9.55 and (ii) 12.61, respectively, based on the average RSV amount (i) in each skin region and (ii) permeation through skin).

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Section: Formulation Of Nanoemulsionsmentioning

confidence: 99%

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

et al. 2020

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“…Detection was carried out at a scattering angle of 90° [14]. From the resulting correlation curves, a 2 nd order analysis was performed to calculate the mean particle size and the standard deviation.…”

Section: Particle Size Characterizationmentioning

confidence: 99%

Mechanistic investigation of biopharmaceutic and pharmacokinetic characteristics of surface engineering of satranidazole nanocrystals

Dhat

Pund

Kokare

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…Besides, resveratrol-loaded lipid-core nanocapsules have higher antioxidant and anti-inflammatory activities compared to the resveratrol alone [37]. Overall, polymeric nanoparticles [38,39], solid lipid nanoparticles [40,41], self-emulsifying drug delivery systems [42,43], nanoemulsions [44,45], liposomes [46,47], nanosuspensions [48] and nanofibers [49] have been developed for delivery of resveratrol and the results have been satisfactory.…”

Section: Resveratrolmentioning

confidence: 99%

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

et al. 2020

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Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria have been derived from bacteria. The main function of mitochondria is the production of ATP. However, this important organelle indirectly protects cells by consuming oxygen in the route of energy generation. It has been found that mitochondria are actively involved in the induction of the intrinsic pathways of apoptosis. So, there have been efforts to sustain mitochondrial homeostasis and inhibit its dysfunction. Notably, due to the potential role of mitochondria in the stimulation of apoptosis, this organelle is a promising target in cancer therapy. Resveratrol is a non-flavonoid polyphenol that exhibits significant pharmacological effects such as antioxidant, anti-diabetic, anti-inflammatory and anti-tumor. The anti-tumor activity of resveratrol may be a consequence of its effect on mitochondria. Multiple studies have investigated the relationship between resveratrol and mitochondria, and it has been demonstrated that resveratrol is able to significantly enhance the concentration of reactive oxygen species, leading to the mitochondrial dysfunction and consequently, apoptosis induction. A number of signaling pathways such as sirtuin and NF-κB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria, and its potential application in cancer therapy.

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Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy

Cited by 55 publications

References 32 publications

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Mechanistic investigation of biopharmaceutic and pharmacokinetic characteristics of surface engineering of satranidazole nanocrystals

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

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