Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy

Yang, Chunhua; Merlin, Didier

doi:10.3390/nano10071424

Cited by 48 publications

(14 citation statements)

References 200 publications

(277 reference statements)

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“…The surface of liposomes can be modified by incorporating various functional motifs. LNPs are widely used not only because of their varieties, but also because they can be loaded with a variety of hydrophobic and hydrophilic therapeutic agents including chemotherapeutics, peptides, proteins, DNA, and RNA as shown in Figure 3 ( Yang and Merlin, 2020 ). In this section, we focused on the current advances and applications of solid lipid NPs and liposomes.…”

Section: Applications Of Oral Anti-crc Nanotherapeuticsmentioning

confidence: 99%

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Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

Ying

Bai

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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Colorectal cancer (CRC) is one of the most common and lethal human malignancies worldwide; however, the therapeutic outcomes in the clinic still are unsatisfactory due to the lack of effective and safe therapeutic regimens. Orally administrable and CRC-targetable drug delivery is an attractive approach for CRC therapy as it improves the efficacy by local drug delivery and reduces systemic toxicity. Currently, chemotherapy remains the mainstay modality for CRC therapy; however, most of chemo drugs have low water solubility and are unstable in the gastrointestinal tract (GIT), poor intestinal permeability, and are susceptible to P-glycoprotein (P-gp) efflux, resulting in limited therapeutic outcomes. Orally administrable nanoformulations hold the great potential for improving the bioavailability of poorly permeable and poorly soluble therapeutics, but there are still limitations associated with these regimes. This review focuses on the barriers for oral drug delivery and various oral therapeutic nanoparticles for the management of CRC.

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Section: Applications Of Oral Anti-crc Nanotherapeuticsmentioning

confidence: 99%

“…FIGURE 3 | Types and structures of lipid-based nanoparticles(Yang and Merlin, 2020). Current lipid-based nanoplatforms include: (A) liposome, (B) core-shell nanoparticle, (C) micelle, (D) solid lipid nanoparticle, (E) nanodisc, and (F) cubosome.…”

mentioning

confidence: 99%

Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

Ying

Bai

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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“…In fact, nanocarriers, depending on their physicochemical properties, stabilize loaded compounds, improving the targetability of the delivery system and concomitantly increase the concentration of the incorporated drug at affected sites. Moreover, this particular in vivo fate avoids drug accumulation in non-affected sites and consequently reduces adverse side effects [ 27 ]. Liposomes are the most well-known and versatile lipid-based nanocarriers due to their unique characteristics.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model

Ribeiro

Albino

Ferreira

et al. 2022

IJMS

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Colorectal cancer is the second leading cause of cancer-related mortality. Many current therapies rely on chemotherapeutic agents with poor specificity for tumor cells. The clinical success of cisplatin has prompted the research and design of a huge number of metal-based complexes as potential chemotherapeutic agents. In this study, two zinc(II) complexes, [ZnL2] and [ZnL(AcO)], where AcO is acetate and L is an organic compound combining 8-hydroxyquinoline and a benzothiazole moiety, were developed and characterized. Analytical and spectroscopic studies, namely, NMR, FTIR, and UV-Vis allowed us to establish the complexes’ structures, demonstrating the ligand-binding versatility: tetradentate in [ZnL(AcO)] and bidentate in [ZnL2]. Complexes were screened in vitro using murine and human colon cancer cells cultured in 2D and 3D settings. In 2D cells, the IC50 values were <22 µM, while in 3D settings, much higher concentrations were required. [ZnL(AcO)] displayed more suitable antiproliferative properties than [ZnL2] and was chosen for further studies. Moreover, based on the weak selectivity of the zinc-based complex towards cancer cell lines in comparison to the non-tumorigenic cell line, its incorporation in long-blood-circulating liposomes was performed, aiming to improve its targetability. The resultant optimized liposomal nanoformulation presented an I.E. of 76% with a mean size under 130 nm and a neutral surface charge and released the metal complex in a pH-dependent manner. The antiproliferative properties of [ZnL(AcO)] were maintained after liposomal incorporation. Preliminary safety assays were carried out through hemolytic activity that never surpassed 2% for the free and liposomal forms of [ZnL(AcO)]. Finally, in a syngeneic murine colon cancer mouse model, while free [ZnL(AcO)] was not able to impair tumor progression, the respective liposomal nanoformulation was able to reduce the relative tumor volume in the same manner as the positive control 5-fluorouracil but, most importantly, using a dosage that was 3-fold lower. Overall, our results show that liposomes were able to solve the solubility issues of the new metal-based complex and target it to tumor sites.

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“…Today, lipids are known to be involved in numerous cellular signaling pathways, including those that regulate cell proliferation, survival, apoptosis, and cell metabolism ( Alabdulkarim et al ., 2012 ). Due to their excellent biocompatibility, lipids are also used as efficient and safe carriers for drug delivery in various formulations ( Yang and Merlin, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Lipids and Their Derivatives in Biomedical Applications

Park

Choi

Kim

et al. 2021

Biomolecules & Therapeutics

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Lipids, which along with carbohydrates and proteins are among the most important nutrients for the living organism, have a variety of biological functions that can be applied widely in biomedicine. A fatty acid, the most fundamental biological lipid, may be classified by length of its aliphatic chain, and the short-, medium-, and long-chain fatty acids and each have distinct biological activities with therapeutic relevance. For example, short-chain fatty acids have immune regulatory activities and could be useful against autoimmune disease; medium-chain fatty acids generate ketogenic metabolites and may be used to control seizure; and some metabolites oxidized from long-chain fatty acids could be used to treat metabolic disorders. Glycerolipids play important roles in pathological environments, such as those of cancers or metabolic disorders, and thus are regarded as a potential therapeutic target. Phospholipids represent the main building unit of the plasma membrane of cells, and play key roles in cellular signaling. Due to their physical properties, glycerophospholipids are frequently used as pharmaceutical ingredients, in addition to being potential novel drug targets for treating disease. Sphingolipids, which comprise another component of the plasma membrane, have their own distinct biological functions and have been investigated in nanotechnological applications such as drug delivery systems. Saccharolipids, which are derived from bacteria, have endotoxin effects that stimulate the immune system. Chemically modified saccharolipids might be useful for cancer immunotherapy or as vaccine adjuvants. This review will address the important biological function of several key lipids and offer critical insights into their potential therapeutic applications.

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Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy

Cited by 48 publications

References 200 publications

Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model

Bioactive Lipids and Their Derivatives in Biomedical Applications

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