Lipid-Based Delivery Systems in Development of Genetic and Subunit Vaccines

Bolhassani, Azam

doi:10.1007/s12033-022-00624-8

Cited by 12 publications

(5 citation statements)

References 137 publications

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“…Therefore, recent advances in preclinical and clinical trials of lipid-based delivery systems that enhance the efficiency and safety of vaccine strategies against various diseases deserve attention. 155 …”

Section: Mechanism Of the Cellular Uptake Of Lnps And Targeting Strat...mentioning

confidence: 99%

Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery

et al. 2023

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Section: Mechanism Of the Cellular Uptake Of Lnps And Targeting Strat...mentioning

confidence: 99%

Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery

et al. 2023

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“…215 Helper lipids, such as dioleoyl phosphatidylethanolamine (DOPE) and 1,2-distearoyl-snglycero-3-phosphocholine (DSPC) utilized in the mRNA-1273 and BNT162b2 COVID-19 vaccines, have been observed to aid endosome escape. 216,217 The World Health Organization (WHO) proclaimed Coronavirus Infectious Disease (COVID-19) a worldwide pandemic; creating COVID-19 vaccines has become essential for the world's population, and many platforms have been researched. The FDA has authorized 12 vaccinations.…”

Section: Genetic and Subunit Vaccines In Preclinical And Clinical Tri...mentioning

confidence: 99%

“…LNP stability is maintained by PEGylated Lipids and Cholesterol, which also affect LNP biodistribution . Helper lipids, such as dioleoyl phosphatidylethanolamine (DOPE) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) utilized in the mRNA-1273 and BNT162b2 COVID-19 vaccines, have been observed to aid endosome escape. , …”

Section: Genetic and Subunit Vaccines In Preclinical And Clinical Tri...mentioning

confidence: 99%

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Gholap,

Gupta,

Kamandar

et al. 2023

ACS Biomater. Sci. Eng.

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Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable advantages over traditional vaccine techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, and the potential for codelivery with adjuvants or immune modulators. This review provides a comprehensive overview of the latest advancements and applications of lipid and non-lipid-based nanovaccines in current vaccination strategies for immunization. The review commences by outlining the fundamental concepts underlying lipid and nonlipid nanovaccine design before delving into the diverse components and production processes employed in their development. Subsequently, a comparative analysis of various nanocarriers is presented, elucidating their distinct physicochemical characteristics and impact on the immune response, along with preclinical and clinical studies. The discussion also highlights how nanotechnology enables the possibility of personalized and combined vaccination techniques, facilitating the creation of tailored nanovaccines to meet the individual patient needs. The ethical aspects concerning the use of nanovaccines, as well as potential safety concerns and public perception, are also addressed. The study underscores the gaps and challenges that must be overcome before adopting nanovaccines in clinical practice. This comprehensive analysis offers vital new insights into lipid and nonlipid nanovaccine status. It emphasizes the significance of continuous research, collaboration among interdisciplinary experts, and regulatory measures to fully unlock the potential of nanotechnology in enhancing immunization and ensuring a healthier, more resilient society.

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“…In comparison to liposomes, virosomes enhance the active substances from proteolytic degradation. Additionally, it is also reported that RNA vaccines are formulated using lipid nanoparticles to increase their stability and immune response (Bolhassani 2023). The most important prevention techniques highlighted based on person-to-person transmission of SARS-CoV-2 by defining the symptoms of COVID-19 patients and their host immune response towards SARS-CoV-2.…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

Biomimetic nanomaterials for pulmonary infections: A prospective view in drug delivery systems

Usharani,

Kanth,

Saravanan

2023

Appl Nanosci

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Respiratory infections are quite challenging due to their complexity in ailments and composition of viral genetic material and their rate of proliferation. In particular, the eradication of viral illness is still a concern, irrespective of advancements in prevention and remedial procedures. The nature of the viral particle with the possibility of rapid transmission is prone to attach on the deposited surface for days together. This antigen expulses due to sneezing or coughing resulted in multiphase turbulent flow, contaminates the surroundings and is carried away by simple touch or inhalation and find newer hosts for instance, SARSCoV-2 aerosols remain viable for about an hour leading to infection. The present review focuses on the remedial aspects of respiratory infections through a knowledge-based approach towards nanosystems. The complete understanding of standard antiviral drugs and the remodelling of these drugs through nanosystems still is the need of the hour. The genetic material and epidemiology of viral antigen, help in redefining standard drugs along with nanocarriers to achieve more feasible and hour-based approach. The main goal of this review is to elaborate on the repurposing of existing standard antiviral drugs and ways to accelerate their mode of action to promote a feasible and hour-based approach. The consolidated three-dimensional approaches aimed at sustained, targeted and optimized levels of drug concentration in the circulating system along with bioactive nanocarriers which could effectively pass the cell membrane were reported. The platforms for nanomaterial evolution depend on nature of source, size, structure, and their unique functionalities (Stable, speedy, and long-lasting recovery procedure). However, the research activities and literature on coronavirus have been overwhelming but the information on the sustainability of nanotherapy in SARS-CoV-2 is still in the developmental stage. Hereby, the clinical aspects of SARS-CoV-2 and the eradication strategy developed for antiviral infections through nanotechnology will pave the way ahead for treating upcoming new variants or other pandemics.

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Lipid-Based Delivery Systems in Development of Genetic and Subunit Vaccines

Cited by 12 publications

References 137 publications

Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery

Lipid-based colloidal nanoparticles for applications in targeted vaccine delivery

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Biomimetic nanomaterials for pulmonary infections: A prospective view in drug delivery systems

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