Lipid and sugar absorption

Turunen, S.; Crailsheim, Karl

doi:10.1007/978-94-009-1519-0_11

Cited by 30 publications

(22 citation statements)

References 101 publications

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“…Photosynthesizing plant tissues contain various glycosyl glycerides (mostly mono-and digalactosylglycerides), phospholipids, and waxes (Harwood, 1980). Digestion of these lipids in insect gut is poorly understood (Turunen and Crailsheim, 1996). It is possible that their peroxidation and generation of MDA from glycerol, fatty acids, and possibly also sugars could facilitate/inhibit lipid utilization.…”

Section: Discussionmentioning

confidence: 99%

Glutathione–ascorbic acid redox cycle and thioredoxin reductase activity in the digestive tract of Leptinotarsa decemlineata (Say)

Krishnan

Kodrı́k

Kłudkiewicz

et al. 2009

Insect Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

Glutathione–ascorbic acid redox cycle and thioredoxin reductase activity in the digestive tract of Leptinotarsa decemlineata (Say)

Krishnan

Kodrı́k

Kłudkiewicz

et al. 2009

Insect Biochemistry and Molecular Biology

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“…In mammals, sodium cholate is synthesized in the liver from cholesterol by cytochrome P450s and facilitates digestion of triacylglycerols (33). It is thought that insects lack bile salts (34) and it is currently unknown if A. gambiae deploys another mechanism to increase lipid solubility.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Mitchell

Stevenson

Müller

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

228

255

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In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles gambiae sensu stricto, a single enzyme, CYP6M2, confers resistance to two classes of insecticide. This is unique evidence in a disease vector of cross-resistance associated with a single metabolic gene that simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from Ghana was characterized using a unique whole-genome microarray. A number of genes were significantly overexpressed compared with two susceptible West African colonies, including genes from metabolic families previously linked to insecticide resistance. One of the most significantly overexpressed probe groups (false-discovery rate-adjusted P < 0.0001) belonged to the cytochrome P450 gene CYP6M2. This gene is associated with pyrethroid resistance in wild A. gambiae s.s. populations) and can metabolize both type I and type II pyrethroids in recombinant protein assays. Using in vitro assays we show that recombinant CYP6M2 is also capable of metabolizing the organochlorine insecticide DDT in the presence of solubilizing factor sodium cholate.

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“…Lipophorin transports different classes of lipids, such as diacylglycerol, phospholipids, cholesterol, hydrocarbons, free fatty acids, between insect various tissues, according to physiological demand (Soulages and Wells 1994, Blacklock and Ryan 1994, Ryan and Van der Horst 2000. Hematophagous insects, such as the triatomines R. prolixus and Panstrongylus megistus, ingest large amounts of blood at each meal and, like it occurs in other insects, digestion causes the release of free fatty acids in midgut lumen which, after absorption, are used in the midgut epithelium for the synthesis of other lipids, as phospholipids, cholesteryl esthers, tri-and diacylglycerol (Tsuchida and Wells 1988, Turunen and Crailsheim 1996, Canavoso et al 2004. Lipids are then transferred to circulating lipophorin that transports them to the organs where they are stored and/or utilized , Coelho et al 1997, Canavoso et al 2004).…”

Section: Lipophorinmentioning

confidence: 99%

Oogenesis and egg development in triatomines: a biochemical approach

Atella

Gondim

Machado

et al. 2005

An. Acad. Bras. Ciênc.

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In triatomines, as well as in other insects, accumulation of yolk is a process in which an extra-ovarian tissue, the fat body, produces yolk proteins that are packed in the egg. The main protein, synthesized by the fat body, which is accumulated inside the oocyte, is vitellogenin. This process is also known as vitellogenesis. There are growing evidences in triatomines that besides fat body the ovary also produces yolk proteins. The way these yolk proteins enter the oocyte will be discussed. Yolk is a complex material composed of proteins, lipids, carbohydrates and other minor components which are packed inside the oocyte in an organized manner. Fertilization triggers embryogenesis, a process where an embryo will develop. During embryogenesis the yolk will be used for the construction of a new individual, the first instar nymph. The challenge for the next decade is to understand how and where these egg proteins are used up together with their non-protein components, in pace with the genetic program of the embryo, which enables cell differentiation (early phase of embryogenesis) and embryo differentiation (late phase) inside the egg.

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Lipid and sugar absorption

Cited by 30 publications

References 101 publications

Glutathione–ascorbic acid redox cycle and thioredoxin reductase activity in the digestive tract of Leptinotarsa decemlineata (Say)

Glutathione–ascorbic acid redox cycle and thioredoxin reductase activity in the digestive tract of Leptinotarsa decemlineata (Say)

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Oogenesis and egg development in triatomines: a biochemical approach

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