Lipid and Lipoprotein Metabolism

p53, a novel regulator of lipid metabolism pathways

“…2A and Supplementary Fig. Of the gene list in Supplementary Table 3, Pltp, and Cel were reported to play crucial roles in lipoprotein metabolism [1,[3][4][5][6]. Of the gene list in Supplementary Table 3, Pltp, and Cel were reported to play crucial roles in lipoprotein metabolism [1,[3][4][5][6].…”

“…p53 augments the activity of secreted PLTP PLTP is secreted from the liver to circulation where it transfers lipids from VLDL/LDL to HDL and thus PLTP is critical for proper lipoprotein transport [3,4]. To demonstrate the consequences of p53-dependent induction of lipid-metabolism genes, we evaluated the activity of secreted hepatic PLTP in HepG2 cells.…”

“…A large fraction of the body lipid content originates from dietary lipids. In addition to lipids offloaded from peripheral tissues, HDL accept lipids from circulating chylomicrons and VLDL/LDL through the activity of phospholipid transfer protein (PLTP), an HDL-bound protein secreted mainly from the liver [3,4]. fatty acids and cholesterol) by various lipases such as carboxyl ester lipase (CEL) [1].…”

Cross-Model Comparison of Transcriptomic Dose–Response of Short-Chain Chlorinated Paraffins

“…Seven genes, including PARP3 (13 out of 15 SCCPs; 13/15), AHR (12/ 15), SIRT3 (12/15), ACAT1 (10/15), FMR1 (10/15), NR1H4 (8/15), and CDK1 (8/15), were dysregulated by more than half of the 15 SCCPs evaluated. AHR, NR1H4, and ACAT1 are three genes commonly involved in lipid metabolism, 43 suggesting that the disruption of lipid homeostasis may be a primary response induced by SCCPs in human liver cells. In particular, PARP3 encodes poly [ADP-ribose] polymerase 3 required for DNA repair, suggesting that SCCPs may induce DNA damage response in HepG2 cells.…”