Lipid and inflammatory biomarker profiles in early insulin resistance

Marcelino-Rodríguez, Itahisa; García, José Oliva; Sánchez, José Juan Alemán; González, Delia Almeida; Coello, Santiago Domínguez; Díaz, Buenaventura Brito; Gannar, Fadoua; Pérez, María del Cristo Rodríguez; Elosúa, Roberto; León, Antonio Cabrera de

doi:10.1007/s00592-016-0885-6

Cited by 9 publications

(4 citation statements)

References 29 publications

(21 reference statements)

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“… 38 Elevated leptin concentrations are related to both WC 35 , 39 and insulin resistance, even in euglycemic patients. 40 The relation between HGF and the metabolic syndrome was previously also shown in 1474 healthy subjects. 41 Of the metabolic syndrome characteristics, HGF is most likely to influence blood pressure, because it mediates remodelling of the vascular wall.…”

Section: Discussionmentioning

confidence: 70%

The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease

Schrover

Graaf

Spiering

et al. 2018

European Journal of Preventive Cardiology

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IntroductionWe evaluated the relationship between adipokine plasma concentrations and body fat distribution and the metabolic syndrome.MethodsIn a cohort of 1215 patients with clinically manifest vascular disease the relation between subcutaneous adipose tissue, visceral adipose tissue, waist circumference, body mass index and plasma concentrations of adipsin, chemerin, monocyte chemoattractant protein-1, migration inhibitory factor, nerve growth factor, resistin, plasma amyloid A1, adiponectin, leptin, plasminogen activator inhibitor-1 and hepatic growth factor were cross-sectionally assessed with linear regression and adjusted for age and gender. The relation between adipokines and the metabolic syndrome was cross-sectionally evaluated using logistic regression. An adipokine profile was developed to measure the effect of combined rather than single adipokines.ResultsAdiposity was related to higher nerve growth factor, hepatic growth factor, migration inhibitory factor, leptin and adipsin and with lower chemerin, plasminogen activator inhibitor-1, resistin, plasma amyloid A1 and adiponectin. The strongest positive relations were between body mass index and adipsin (β 0.247; 95% CI 0.137–0.356) and leptin (β 0.266; 95% CI 0.207–0.324); the strongest negative relations were between body mass index and plasma amyloid A1 (β –0.266; 95% CI –0.386 to –0.146) and visceral adipose tissue and adiponectin (β –0.168; 95% CI –0.226 to –0.111). There was no relation between subcutaneous adipose tissue and adipokines. Odds for the metabolic syndrome were higher with each 1 SD higher hepatic growth factor (OR 1.21; 95% CI 1.06–1.38) and leptin (OR 1.26; 95% CI 1.10–1.45) and lower with each 1 SD higher adiponectin (OR 0.73; 95% CI 0.64–0.83) and resistin (OR 0.85; 95% CI 0.74–0.97). The adipokine profile was related to the metabolic syndrome (OR 1.03; 95% CI 1.00–1.06).ConclusionPlasma concentrations of adipokines are related to obesity and body fat distribution. The relation between adipokine concentrations and the metabolic syndrome is independent of visceral adipose tissue.

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Section: Discussionmentioning

confidence: 70%

The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease

Schrover

Graaf

Spiering

et al. 2018

European Journal of Preventive Cardiology

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“…Several studies have also reported a close association of inflammatory markers such as hsCRP, adiponectin, and leptin with IR, and type 2 DM. Levels of leptin, adiponectin, and CRP were significantly different between early IR group and no insulin resistance group among non‐diabetic subjects . hsCRP and other inflammatory markers were raised significantly in prediabetes and diabetes subjects.…”

Section: Discussionmentioning

confidence: 85%

Association of oxidative stress and inflammatory markers with chronic stress in patients with newly diagnosed type 2 diabetes

Siddiqui

Desai

Sharma

et al. 2019

Diabetes Metabolism Res

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Aims: Chronic stress is associated with increased risk of type 2 diabetes. Oxidative stress and inflammation are potential mediators of this risk. This study was conducted to investigate the association of oxidative stress and inflammatory markers with chronic stress and newly diagnosed type 2 diabetes. Methods: Oxidative stress/antioxidant status (malondialdehyde [MDA], reduce glutathione [GSH], glutathione reductase [GR], glutathione peroxidase [GPx], catalase [CAT], superoxide dismutase [SOD]), inflammatory markers (highly sensitive Creactive protein [hsCRP], adiponectin, leptin), chronic stress levels as assessed by stress scales-presumptive stressful life events scale (PSLES), perceived stress scale (PSS), sense of coherence (SOC) and stress biomarker-salivary cortisol in 125 subjects with newly detected diabetes mellitus (NDDM) were compared with an equal number of age and sex matched subjects with normal glucose tolerance (NGT).Results: NDDM subjects as compared with NGT had significantly increased MDA (P < 0.001), hsCRP (P < 0.001), and leptin (P = 0.014) levels and increased GR (P = 0.043) and SOD (P < 0.001) activity along with decreased GSH (P < 0.001) and adiponectin (P < 0.001) levels. They also had significantly higher PSLES-LT and PSS and lower SOC scores along with elevated levels of 10:00 PM salivary cortisol and post dexamethasone salivary cortisol as compared with NGT.

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“…Type 2 diabetes is associated with increased inflammation, which can contribute to insulin resistance and is shown to be detrimental to many tissues including pancreatic β-cells [ 24 , 25 ]. Resistin, a hormone secreted by adipocytes, impairs glucose tolerance and insulin sensitivity in mice [ 26 ] and has been associated with insulin resistance in humans [ 27 , 28 ]. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory chemokine that can induce insulin resistance [ 29 ] and circulating levels of this chemokine are increased in patients with type 2 diabetes [ 30 – 32 ].…”

Section: Resultsmentioning

confidence: 99%

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

et al. 2017

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Thymoquinone, a natural occurring quinone and the main bioactive component of plant Nigella sativa, undergoes intracellular redox cycling and re-oxidizes NADH to NAD+. TQ administration (20 mg/kg/bw/day) to the Diet-Induced Obesity (DIO) mice reduced their diabetic phenotype by decreasing fasting blood glucose and fasting insulin levels, and improved glucose tolerance and insulin sensitivity as evaluated by oral glucose and insulin tolerance tests (OGTT and ITT). Furthermore, TQ decreased serum cholesterol levels and liver triglycerides, increased protein expression of phosphorylated Akt, decreased serum levels of inflammatory markers resistin and MCP-1, and decreased NADH/NAD+ ratio. These changes were paralleled by an increase in phosphorylated SIRT-1 and AMPKα in liver and phosphorylated SIRT-1 in skeletal muscle. TQ also increased insulin sensitivity in insulin-resistant HepG2 cells via a SIRT-1-dependent mechanism. These findings are consistent with the TQ-dependent re-oxidation of NADH to NAD+, which stimulates glucose and fatty acid oxidation and activation of SIRT-1-dependent pathways. Taken together, these results demonstrate that TQ ameliorates the diabetic phenotype in the DIO mouse model of type 2 diabetes.

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Lipid and inflammatory biomarker profiles in early insulin resistance

Abstract: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.

Cited by 9 publications

References 29 publications

The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease

The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease

Association of oxidative stress and inflammatory markers with chronic stress in patients with newly diagnosed type 2 diabetes

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

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