Lipid accumulation product is a reliable indicator for identifying metabolic syndrome: the China Multi-Ethnic Cohort (CMEC) Study

Abstract

Background Previous studies have shown that lipid accumulation product (LAP) was associated with the risk of cardiometabolic disease. It is not clear whether LAP could be used as a marker to identify metabolic syndrome (MetS) among Chinese ethnic groups. Aim: To assess the reliability of LAP as a maker to identify MetS among Dong adults. Design: Population-based cross-sectional study. Method We included 6494 Dong individuals (1403 patients) aged 30–79 years from southwest China. MetS was established by Chinese Diabetes Society. Logistic regression model was utilized to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic (ROC) curve was utilized to calculate area under the ROC curve (AUC) and 95% CIs to obtain the identification ability for MetS. Results The risk of MetS was increased with per 5 units increase of LAP (OR 1.37 [95% CI, 1.34–1.39]). Similar results were found in subgroup analyses and sensitivity analyses. Clustered metabolic risk associated with per 5 units increase of LAP was observed for people with 1 (OR 1.59 [95% CI, 1.53–1.65]), 2 (2.15 [2.06–2.24]), 3 (2.59 [2.48–2.71]), 4 (2.81 [2.69–2.95]) and 5 (3.03 [2.87–3.21]) MetS components. LAP presented higher AUC (0.915 [95% CI, 0.907–0.923]) than other included obesity indices (P < 0.05). Conclusion These data support evidence that LAP was related to the risk of MetS, had a high AUC and could be a reliable index for identifying MetS patients among Dong adults in Chinese.

Association Between the Cardiometabolic Index and Hyperuricemia in an Asymptomatic Population with Normal Body Mass Index

“…In 2006, the lipid accumulation product (LAP) 12 was introduced, which incorporated triglycerides (TG) and WC and was adjusted by gender, which was thought to offer a better evaluation of visceral adipose tissue and had a stronger association with metabolic status. Some studies 13 , 14 reported that LAP was an efficient marker of MS in general adult populations. In 2015, the cardiometabolic index (CMI) 15 was proposed as a new index to evaluate visceral obesity by using blood lipid parameters and WHtR.…”

Association of Tibetan Habitual Food and Metabolic Syndrome Among Tibetan People in China: A Cross-Sectional Study

“…study from CMEC that lipid accumulation product could be a reliable index for identifying MetS. (15). Besides, a 5-year followup indicated that adults with a low HDL level were more likely to develop MetS in the long run (16).…”

Resting heart rate is associated with the risk of metabolic syndrome and its components among Dong adults in southwest China: Cross‐sectional findings of the China Multi‐Ethnic Cohort Study

“…The sociodemographic characteristics, health‐related behaviours and medical history, including sex, age, marital status, residency, educational level, smoking status, alcohol drinking, tea intake, beverage intake, physical activity, taking antiarrhythmic or antihypertensive drugs, family history of hypertension or diabetes, coronary heart disease, stroke and abnormal thyroid function were collected by face‐to‐face interviews. Details about the investigation were previously published 21,22 …”

“…Details about the investigation were previously published. 21,22 Smokers were defined as people who had smoked 100 or more cigarettes during their lifetime. 23 Alcohol drinkers were defined as having consumed alcohol once or more times per week in the past half year.…”