Lipid accumulation product and metabolic syndrome: a population-based study in northern Iran, Amol

Motamed, Nima; Rastgar, Sara; Hemmasi, Gholamreza; Maadi, Mansooreh; Zamani, Farhad

doi:10.1007/s40618-015-0369-5

Cited by 64 publications

(73 citation statements)

References 24 publications

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“…In addition, in fact, men have, on average, more visceral fat and less subcutaneous fat [39]. In our results, the LAP index was the parameter with the highest sensitivity discriminating individuals with and without MetS in the ROC curve, with AUC 0.9489 ( Figure 7 and Figure 8), which is consistent with several population studies conducted in individuals from China [41,42] and Iran, which showed the same conclusions [29], similarly to Abruzzese et al [43] in a population of Latin America, found similar results, with similar cutoff points for different populations and ethnic groups. In this study, LAP and VAI were acceptable indicators for MetS screening, however LAP presented a better correlation between WC and triglyceride values, whereas VAI was the index that was worse correlated with the rest of the variables that make up ( Table 2).…”

Section: Discussionsupporting

confidence: 90%

“…The published population studies that have used the fats indexes in the early detection of MetS and other cardiovascular risks in individuals distributed according to gender and race (African American, Caucasian, Asian, Hindu) have encouraging results, showing that they are superior to BMI and WC [24,28,29]. In the Venezuelan population, no published studies were available to validate the use of fats indexes; however, it was found that Barrios and Rivero used the Body Adiposity Index (BAI) in 90 patients from the Lara state, concluding that BAI did not represent a reliable index to determine new cases of MetS [30].…”

Section: Introductionmentioning

confidence: 99%

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Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Velasco¹

2017

J.Pharm Pharm Scien

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Objective: To evaluate and compare the relationship between Lipid Accumulation Product (LAP) and Visceral Adiposity index (VAI) with the components of the metabolic syndrome (MetS) in Venezuelan adults. Methods:Cross-sectional, observational analytical study, comprising 332 individuals selected at the Endocrine Service of the Hospital Militar "Dr Carlos Arvelo". Anthropometry (BMI, WC) and fasting biochemical parameters (TG, HDLcholesterol) were measured and the LAP and VAI (fats indexes) were estimated. Patients were classified into 3 groups with and without Metabolic Syndrome following the ATPIII criteria and a group with Cardiovascular Disease (CVD).Results: 73.17% of the individuals were female and 26.82% were male, with 123 (37.04%) individuals without Metabolic Syndrome (non-MetS), 137 (41.27%) with Metabolic Syndrome and 72 (21.68%) with CVD. In the group without Metabolic Syndrome, we found: LAP (6.72 -26.28) and VAI (0.71 -1.85), for the group with Metabolic Syndrome: LAP (42.09 -108.57) and VAI (1.11 -4.15), with significant differences between groups (p <0.005) and in the CVD group and .Discussion: the results obtained agreed with studies carried out in different populations and ethnic groups (Asia, Middle East and Latin America), indicating that the LAP index obtained better precision for MetS screening, regardless of gender and BMI, the VAI index was best predictor of Cardiovascular Disease.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Velasco¹

2017

J.Pharm Pharm Scien

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“…In addition, two studies 22,26 did not adequately define the age group of the elderly. While Motamed et al 26 did not stratify the results between adults and the elderly, Tellechea et al 22 considered the elderly group to be aged between 45 and 65. These facts limit the understanding of this indicator's performance, specifically among the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…Tellechea et al 22 , Chiang & Koo 24 and Motamed et al 26 also observed the high predictive capacity of LAP to identify MetS (AUC higher than 0.90). Among these studies, the lowest LAP cut-off point to identify MetS was reported by Chiang & Koo 24 (31.6 for both sexes).…”

Section: Clinical Indicatorsmentioning

confidence: 92%

“…3 Most of the studies analysed evaluated a mixed population, stratified by sex and/or age range. The cut-off point for LAP suggested by the authors [22][23][24][25][26] varied from 31.6 to 51.8, with a difference between the sexes (Table 4). Among men, the LAP AUC to predict MetS varied from 0.84 to 0.937, while for women the lowest AUC was 0.78 and highest was 0.904 (Table 4).…”

Section: Anthropometric Indicatorsmentioning

confidence: 99%

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Predictors of Metabolic Syndrome in the Elderly: A Review

Oliveira

Costa²,

Roriz³

et al. 2017

International Journal of Cardiovascular Sciences

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The article aimed to critically analyse studies which evaluated the capacity of anthropometric and clinical indicators to predict MetS in the elderly. Bibliographical research was performed using the electronic databasese Medline/PubMed, LILACS e SciELO , references from selected articles and contact with several authors. Twenty one articles involving anthropometric and clinical indicators in the elderly were analysed, using different MS criteria. Fourteen studies report anthropometric indicators, being the waist circumference (WC) and waist-to-height ratio (WHtR), described as the best MS predictors, with the area under the ROC curve (AUC) over 0.70 (p < 0.05). The neck circumference was also described as an alternative indicator but with less discriminatory power. Lipid accumulation product (LAP) was the parameter with the best performance to identify MS, with an AUC over 0.85 and efficiency greater than 70%. The WC, WHtR and LAP indicators were the most sensitive for predicting MS. The use of these parameters may facilitate the early identification of MS, with good accuracy and low cost. In addition, it is important to determine specific cutoff points for the elderly, since obesity alone does not appear to be a strong predictor of MS in the elderly.

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Cardiometabolic syndrome among general adult population in Ghana: The role of lipid accumulation product, waist circumference‐triglyceride index, and triglyceride‐glucose index as surrogate indicators

Anto,

Frimpong,

Boadu

et al. 2023

Health Science Reports

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Background: Visceral obesity and insulin resistance contribute to developing cardiometabolic syndrome (MetS). We investigated the predictive abilities of lipid accumulation product (LAP), waist circumference-triglyceride index (WTI), and triglyceride-glucose (TyG) index for MetS screening among the general Ghanaian adults. Methods:The final prospective analysis included 4740 healthy adults aged 30-90 years from three communities comprising Ejisu, Konongo, and Ashanti Akim Agogo in Ghana. Self-structured questionnaire pretested was used to collect sociodemographic, anthropometric, and clinical data. Blood samples were taken after fasting to measure glucose and lipid levels. LAP, WTI, and TyG were calculated from standard equations. MetS was defined by the International Diabetes Federation criteria. Receiver operating characteristic (ROC) curves and multivariable logistic regression were utilized to evaluate the potential of the three indices in identifying MetS.Results: Of the 4740 participants, 39.7% had MetS. MetS was more common in females (50.3%) than in males (22.2%). Overall, LAP ≥ 27.52 yielded as the best index for MetS with the highest area under the ROC curve (AUC) (0.866). At cut-off LAP point of ≥23.87 in males and ≥33.32 in females, an AUC of 0.951 and 0.790 was identified in MetS prediction, respectively. LAP was an independent risk measure of MetS for both males (45.6-fold) and females (3.7-fold) whereas TyG was an independent risk measure for females (3.7-fold) only.

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Lipid accumulation product and metabolic syndrome: a population-based study in northern Iran, Amol

Abstract: LAP has a strong and reliable diagnostic accuracy for MetS in Iranian population in the north of Iran. LAP showed a better predictability than other obesity indexes assessed in the present study.

Cited by 64 publications

References 24 publications

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Predictors of Metabolic Syndrome in the Elderly: A Review

Cardiometabolic syndrome among general adult population in Ghana: The role of lipid accumulation product, waist circumference‐triglyceride index, and triglyceride‐glucose index as surrogate indicators

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