Lipid Absorption in Newborn Young of Guinea Pigs Fed a Protein-Deficient Diet during Gestation

Zeman, Frances J.; Widdowson, E. M.

doi:10.1159/000240666

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…In contrast with the rat, the offspring of protein-deprived guinea pigs have been described as having intestinal villi that are longer, narrower, and more numerous than the controls. In addition, these animals showed a more efficient absorption of p4C]oleic acid and P4C]triolein than did control young (Zeman and Widdowson, 1974).…”

Section: Fetal Growthmentioning

confidence: 79%

Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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Section: Fetal Growthmentioning

confidence: 79%

Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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“…Alth ough the ultrastructural morphology of the small intestine microvilli of zinc-deficient rat s was shown to be relati vely intact (16), it is po ssible that their function al integrity was affected. Our finding s are not related to the relative decrease in the weight of the zinc-deficient rat s compared to the controls, becau se sev eral in vesti gators ha ve sho wn an increase in the tran sport of several substrates such as glucose (17), amino acid s (18) , and fat (19) with protein-calorie malnutrition.…”

Section: Discussionmentioning

confidence: 48%

Transport of Electrolytes, Water, and Glucose in Zinc Deficiency

Ghishan

1984

J. pediatr. gastroenterol. nutr.

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Zinc deficiency in humans and animals results in failure to thrive, skin lesions, loss of hair, and diarrhea. The mechanism underlying the diarrhea seen in zinc deficiency is not known. Therefore, the current study was designed to investigate net transport of water, electrolytes, and glucose from segments of small and large intestine in zinc‐deficient, pair‐fed control, and ad libitumfed rats. An in vivo single‐pass perfusion study was used. The results indicate that net water and sodium transport from the small and large intestine of zinc‐deficient rats was significantly decreased compared to corresponding mean values for pair‐fed controls and for ad libitum‐fed rats. Net absorption of glucose and net secretion of potassium were not significantly different in the three groups. The results are in agreement with previous investigations showing decreased sodium transport in leukocytes and renal tubules of zinc‐deficient animals and suggest that zinc may have a role in modulating membrane permeability.

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“…Thus, our current study demonstrates that zinc is transported along the entire intestinal tract including the colon, that rates of transport in suckling rats are significantly greater than in adolescent rats, and that malnutrition has no effect on zinc transport at the preweaning period but an enhanced effect on postweaning rats. Such a compensatory mechanism has been noted for the hexoses, amino acids, and lipids in the small intestine of malnourished suckling and adolescent rats (24,25).…”

Section: Discussionmentioning

confidence: 80%

In Vivo Intestinal Zinc Transport in Rats

Meneely,

Ghishan

1982

J. pediatr. gastroenterol. nutr.

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SummaryWe compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2‐week‐old (suckling) and 6‐week‐old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corresponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.

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Lipid Absorption in Newborn Young of Guinea Pigs Fed a Protein-Deficient Diet during Gestation

Cited by 5 publications

References 5 publications

Nutrition and Pregnancy

Nutrition and Pregnancy

Transport of Electrolytes, Water, and Glucose in Zinc Deficiency

In Vivo Intestinal Zinc Transport in Rats

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