Lipid abnormality, current diabetes and age affect erectile hardness: An analysis of data from complete medical checkups carried out at a single hospital

Ishikawa, Kiyomu; Sasaki, Hidetada; Tanifuji, S.; Kurokawa, Ichiro; Sugishita, Hiroki; Hashimoto, Yu; Hayashi, Keiichiro; Shichijo, Takeshi

doi:10.1111/iju.14200

Cited by 4 publications

(5 citation statements)

References 12 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the significant increase in atherogenic risk caused by dyslipidaemia, the significant contribution of vascular mechanisms to ED is unsurprising. 84 Dyslipidaemia is an independent risk factor for ED in patients with DM, 85 and patients with both DM and ED have a 2.3‐fold higher risk for dyslipidaemia. 69 , 86 High LDL levels, low HDL levels, 87 and hypertriglyceridemia 88 have been linked to ED 89 despite the difficulty of evaluating the isolated effects of a single lipid class.…”

Section: The ‘Complicated Role’ Of Complications and Cofactors In The...mentioning

confidence: 99%

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Defeudis

Mazzilli

Tenuta

et al. 2021

Diabetes Metabolism Res

109

View full text Add to dashboard Cite

Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common chronic diseases. The incidence and prevalence of DM have been increasing over the years. The complications of DM represent a serious health problem. The long-term complications include macroangiopathy, microangiopathy and neuropathy as well as sexual dysfunction (SD) in both men and women. Erectile dysfunction (ED) has been considered the most important SD in men with DM. The prevalence of ED is approximately 3.5-fold higher in men with DM than in those without DM. Common risk factors for the development of DM and its complications include sedentary lifestyle, overweight/ obesity and increased caloric consumption. Although lifestyle changes may help improve sexual function, specific treatments are often needed. This study aims to review the definition and prevalence of ED in DM, the impact of DM complications and DM treatment on ED and, finally, the current and emerging therapies for ED in patients with DM.

show abstract

Section: The ‘Complicated Role’ Of Complications and Cofactors In The...mentioning

confidence: 99%

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Defeudis

Mazzilli

Tenuta

et al. 2021

Diabetes Metabolism Res

109

View full text Add to dashboard Cite

show abstract

“…4 Another study at the Yokohama Shin-midori Hospital in Japan obtained an EHS score 2 increases at a higher age, namely by 50.0% at the age of 60 -69 years and reached 55.3% at the age of 70 -79 years. 10 From the statistical analysis of the results of the IIEF-5 questionnaire, no significant relationship was found between the age factor of BPH sufferers and the occurrence of ED. This result aligns with research conducted at Al-Ihsan Hospital, Bandung Regency, which found no significant relationship between age and ED in BPH sufferers.…”

Section: Discussionmentioning

confidence: 96%

“…Meanwhile, a study in Japan found a significant relationship between hypertension and a decrease in the level of erectile hardness. 10 The erectile function of the penis is based on vascular networks. Structural or functional abnormalities of the penile blood vessels can interfere with a person's ability to get and maintain optimal erections.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Age, Hypertension, and Type-2 Diabetes Mellitus in Benign Prostatic Hyperplasia Patients with Erectile Dysfunction

Rabbani,

Satyagraha,

Irnandi

2023

IABJ

View full text Add to dashboard Cite

Based on epidemiological data, the incidence of ED and BPH increases with the same risk factors, such as age, metabolic disease, and others. Aim: This study aimed to determine the prevalence of ED and its relationship to age and the presence of hypertension (HT) and type-2 diabetes mellitus (T2DM) comorbid in BPH patients. This is a cross-sectional study conducted at RSUD Dr. Saiful Anwar and Hermina Hospital Tangku-banprahu Malang utilizes two questionnaires, including the translated version of The Interna-tional Index of Erectile Function (IIEF-5) and Erectile Hardness Score (EHS) in Indonesian. There were 44 research subjects with only 21 respondents to the IIEF-5 question-naire, while the EHS questionnaire was given to all subjects. The prevalence of ED was found to reach 100.0% at the age of 70-79 years through the IIEF-5 questionnaire and aged ³ 80 years through the EHS questionnaire. The prevalence of ED in BPH patients with HT was found to be higher than non-HT patients through both questionnaires. The prevalence of ED in BPH patients with T2DM was found to be higher through the IIEF-5 questionnaire and slight-ly lower through the EHS questionnaire than non-T2DM patients. Age had a significant rela-tionship with ED through the EHS questionnaire (p = 0.006), while no significant relationship was found through the IIEF-5 questionnaire (p = 1.000). HT and T2DM did not have a signif-icant relationship with ED (IIEF-5: p = 0.229 and 0.526; EHS: p = 0.518 and 1.000). The prevalence of ED in BPH patients increases with age and the presence of comorbid HT and T2DM. Even so, there was no significant relationship between HT and T2DM with ED in BPH patients. A significant relationship between age and ED was only found in the EHS questionnaire but not in the IIEF-5 questionnaire.

show abstract

“…Dyslipidemia also contributes to endothelial damage through increased atherogenic risk [ 27 ]. For this reason, dyslipidemia is considered an independent risk factor for the development of ED in patients with DM [ 28 ]. However, although Group A showed significantly higher prevalence of hypertension and dyslipidemia, we found no significant differences of ED severity when clustering patients with DM according to the presence/absence of these comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction Severity: The Role of Glycometabolic Compensation and Antihyperglycemic Drugs

Zamponi

Defeudis

Federico

et al. 2022

JCM

View full text Add to dashboard Cite

Background: The aim of this study was to evaluate the prevalence of DM among patients with ED and the impact of glycometabolic compensation and antihyperglycemic treatment on ED severity. Methods: In total, 1332 patients with ED were enrolled. The diagnosis was performed through the International-Index-of-Erectile-Function questionnaire. ED severity was considered according to presence/absence of spontaneous erections, maintenance/achievement deficiency and response to PDE5-i. DM patients were clustered according to antihyperglycemic treatment: “metformin”/“insulin”/“old antihyperglycemic drugs”/“new antihyperglycemic drugs”. Results: The prevalence of DM patients was 15.8% (Group A, patients with ED and DM). Among these, the prevalence of spontaneous erections (21.0%) was lower than in the remaining patients (Group B, patients with ED without DM) (32.0%, p < 0.001). The prevalence of poor response to PDE5-i was lower in Group B (10.0%) than in Group A (35.0%, p < 0.001). Patients with good response to PDE5-i therapy showed lower HbA1c values than patients with poor/no response (6.6 ± 1.1% vs. 7.7 ± 1.9%, p = 0.02). The prevalence of absent response to PDE5-i was higher in patients treated with old antidiabetic drugs than in the population treated with new drugs (p = 0.03). Conclusion: The severity of ED and lower response to PDE5-i were higher in DM patients. A better glycometabolic profile, as well as new antihyperglycemic drugs, seem to have a positive effect on ED.

show abstract

Lipid abnormality, current diabetes and age affect erectile hardness: An analysis of data from complete medical checkups carried out at a single hospital

Cited by 4 publications

References 12 publications

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Relationship between Age, Hypertension, and Type-2 Diabetes Mellitus in Benign Prostatic Hyperplasia Patients with Erectile Dysfunction

Erectile Dysfunction Severity: The Role of Glycometabolic Compensation and Antihyperglycemic Drugs

Contact Info

Product

Resources

About