Lipemia retinalis in an infant treated for retinopathy of prematurity

Jain, Astha; Mochi, Thirumalesh B; Braganza, Sherine; Agrawal, Shruti; Shetty, Bhujang; Pachiyappan, Balachandran

doi:10.1016/j.jaapos.2017.05.021

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…Moreover, various ocular and retinal pathologies can be diagnosed incidentally during dilated routine examinations. 6 Several metabolic disorders can also be detected in newborns during a thorough ophthalmic examination, even in very early stages before any prominent symptoms and signs become evident. In 1880, Heyl first described LR, which is characterized by milky-creamy white colored retinal vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Isolated hyperlipidemia without accompanying hypertriglyceridemia does not present with LR. 1 , 2 , 3 , 4 , 5 , 6 , 7 Hypertriglyceridemia may also occur in familial disorders like apolipoprotein C-II deficiency, LPL deficiency, and endogenous circulating low-density lipoprotein inhibitor. 1 Yin et al 8 reported a homozygous p.G215E mutation in the LPL gene in a 6-week-old full-term baby with hypertriglyceridemia and LR.…”

Section: Discussionmentioning

confidence: 99%

“…Babies born preterm and those with intrauterine growth restriction may be more prone to LR due to major risk factors for hypertriglyceridemia such as low LPL activity, parenteral nutrition, and consumption of medium chain triglyceride formulas, which are very common supplements for low-birth-weight infants. 6 , 7 , 8 Persistence of uncontrolled high serum levels of cholesterol and triglycerides may lead to possibly fatal morbidities including premature atherosclerosis and coronary artery disease, pancreatitis, and hepatic failure, especially in preterm and term newborns and infants. 6 , 7 , 8 , 9 , 10 Hence, early diagnosis of LR in such cases is crucial.…”

Section: Discussionmentioning

confidence: 99%

“… 6 , 7 , 8 Persistence of uncontrolled high serum levels of cholesterol and triglycerides may lead to possibly fatal morbidities including premature atherosclerosis and coronary artery disease, pancreatitis, and hepatic failure, especially in preterm and term newborns and infants. 6 , 7 , 8 , 9 , 10 Hence, early diagnosis of LR in such cases is crucial. Although it is known that LR generally does not affect visual acuity in sufferers, Dinc et al 11 reported a pregnant Turkish women with no family history of hyperlipidemia who developed bilateral severe visual deterioration and whose visual acuity improved after delivery and increased to 20/20 with a normal fundoscopic appearance in both eyes after low-fat diet, physical exercise, and drug treatment with 3-hydroxy-3-methyl-glutaryl-coenzyme A inhibitor.…”

Section: Discussionmentioning

confidence: 99%

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Lipemia Retinalis Diagnosed Incidentally After Laser Photocoagulation Treatment for Retinopathy of Prematurity

Öztürk¹,

Yiğitaslan²,

Kisa³

et al. 2021

tjo

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A preterm infant who underwent bilateral laser photocoagulation for the treatment of stage 3 retinopathy of prematurity (ROP) is presented because she was incidentally diagnosed with grade 3 lipemia retinalis by dilated fundoscopy at post-laser 2 weeks. Meticulous ophthalmologic examination is imperative in premature newborns for not only ROP screening but also detecting any concomitant ocular abnormalities, which can be sight-threatening or even life-threatening.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Lipemia Retinalis Diagnosed Incidentally After Laser Photocoagulation Treatment for Retinopathy of Prematurity

Öztürk¹,

Yiğitaslan²,

Kisa³

et al. 2021

tjo

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show abstract

“…Literatürde, PR için tarama muayenesi esnasında LR tanısı alan olgular da mevcuttur. [84][85][86][87] Preterm doğan ve intrauterin büyüme kısıtlılığı olan bebekler, düşük lipoprotein lipaz aktivitesi, parenteral beslenme ve orta zincirli TG formulalarının yaygın olarak tüketimi gibi risk faktörleri nedeniyle LR' e daha yatkın olabilir. Hastalığa bağlı retina değişiklikleri, serum TG seviyeleri normale döndüğünde düzelir.…”

Section: Lipemia Retinalisunclassified

Hyperhomocysteinemia, Hyperlipidemia and Retina

2023

Güncel Retina (Current Retina)

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Hyperhomocysteinemia is a disease with an increase in the plasma level of homocysteine, an intermediate of methionine metabolism, and predisposes to thrombosis. It is a well-established risk factor for occlusive cardiovascular illnesses and has been linked to ocular pathologies such as retinal vascular disorders, age-related macular degeneration, and most notably ectopia lentis. Lipids compose approximately 20% of the dry weight of the retina. Apart from their structural significance, lipids also serve a critical function in providing the necessary energy for the metabolic needs of the retina. Hyperlipidemia is described as an abnormally high level of blood cholesterol and triglycerides and is a major risk factor for atherosclerosis. It may increase the risk of retinal vascular disorders secondary to atherosclerosis-like processes in the retina. Through the inflammatory process they generate, hyperhomocysteinemia and hyperlipidemia may also contribute to the progression of retinal vascular disorders such as diabetic and hypertensive retinopathy and retinopathy of prematurity.

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Alterations in ocular microcirculation and oxygen metabolism in patients with lipemia retinalis

Alsarhani

Adel²,

Alamri³

et al. 2022

BMC Ophthalmol

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Purpose The study aims to assess the alterations in retinal oxygen saturation and retinal and choroidal blood flow in lipemia retinalis. Methods This was a cross-sectional study on 10 eyes (5 patients) with history of lipemia retinalis. The study comprised 10 eyes with documented history of lipemia retinalis and 10 participants as healthy controls. Patients with a confirmed history of lipemia retinalis were grouped into two cohorts based on their most recent fundus examination: untreated lipemia retinalis (abnormal fundus) and resolved lipemia retinalis (normal fundus). Both retinal arteriolar and venular oxygen saturation were measured using the non-invasive spectrophotometric retinal oximeter (Oxymap T1). The mean blur rate (MBR) of the optic nerve and choroidal blood flow were analyzed using a laser speckle flowgraph (LSFG). Results Patients with untreated lipemia retinalis had a significantly higher retinal arteriolar and venular oxygen saturation than that of the other two groups (p < 0.001). Moreover, patients with untreated lipemia retinalis had significantly smaller retinal arteriolar and venular diameters (p < 0.001). On LSFG, there was a significant difference in the overall MBR (p = 0.007) and vessel MBR of the optic nerve between the groups (p = 0.011). The patients with history of lipemia retinalis (untreated and resolved) exhibited a high overall MBR and vessel MBR of the optic nerve than that of the control group. There was a significant elevation of the optic nerve (p = 0.002) and choroidal blowout score (p < 0.001), while the resistivity index of the optic nerve (p = 0.001) and choroids (p = 0.002) was significantly lower in patients with resolved and untreated lipemia retinalis. Conclusions There was a significant alteration in retinal oximetry, in untreated lipemia retinalis, and in retinal blood flow, in both the resolved and untreated groups. The increase in retinal blood flow and oxygen saturation may elucidate the preservation of visual acuity and function despite the fundus changes observed in lipemia retinalis.

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Lipemia retinalis in an infant treated for retinopathy of prematurity

Cited by 4 publications

References 10 publications

Lipemia Retinalis Diagnosed Incidentally After Laser Photocoagulation Treatment for Retinopathy of Prematurity

Lipemia Retinalis Diagnosed Incidentally After Laser Photocoagulation Treatment for Retinopathy of Prematurity

Hyperhomocysteinemia, Hyperlipidemia and Retina

Alterations in ocular microcirculation and oxygen metabolism in patients with lipemia retinalis

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