Lipemia as a determinant of development of an acute pancreatitis: investigation «case-control»

Abstract

Objective. To establish the connection between lipemia and course of an acute pancreatitis.
 Materials and methods. The investigation design: «case - control». There were incorporated 93 patients, suffering an acute pancreatitis. Group «case» - 11 patients with acute pancreatitis and lipemia, Group «control» - 82 patients with acute pancreatitis without lipemia. Interrelationship was investigated in accordance to the relative risk index between lipemia and the factors signs: the acute pancreatitis severity degree, recurrent course of the disease, presence of diabetes mellitus and alcoholic anamnesis.
 Results. Comparative analysis of rate for the factors signs revealing have established, that possibility of development of severe acute pancreatitis and possibility of the alcohol-induced acute pancreatitis occurrence in groups of patients did not differ statistically meaningful (p > 0.05). While comparing a rate of the acute pancreatitis recurrence and the diabetes mellitus presence in groups of patients there were differences revealed on the significant level: p=0.02 and p=0.04 accordingly. Lipemia constitutes a risk factor for recurrent course of an acute pancreatitis and diabetes mellitus in patients with an acute pancreatitis: relative risk 7.5 (95% CI 1.8 - 26.6, p=0.02), RR 6.1 (95% CI 1.2 - 28.7, p= 0.02) accordingly.
 Conclusion. Presence of lipemia did not impact the acute pancreatitis severity (p=0.98). Possibility of the acute pancreatitis recurrence in patients with lipemia in 7 times is higher, than in patients with an acute pancreatitis without lipemia (p=0.02). Possibility of diabetes mellitus presence in patients with an acute pancreatitis and lipemia is in 6 times higher, than in patients wihout lipemia (p= 0.02). Timely diagnosis and correction of a dislipoproteinemia constitutes a prophylactic measure, which is capable to lower the rate of an acute pancreatitis recurrence.