Lipase-powered asymmetric silica nanomotors with a tailored head-tail structure for enhanced mucus penetration

Ban, Wenhuang; Qu, Jingjing; Cai, Larry; Fu, Jianye; Wu, Weixi; Song, Hao; Yu, Chengzhong; Tang, Jie

doi:10.1016/j.apmt.2023.101916

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…In another similar work by Ban et al 90 showed fabrication of lipase functionalized nanomotor which can be self-propelled in physiological media for imparting enhanced transport in biological media. In one of our previous work, 6 we showed deployment of micro/-motor dynamics for the active transport of ions targeting electric double layer charging on a surface which is placed at a distance location from the higher ion concentration.…”

Section: Discussion On Role Of Mnms In Electrochemical Biosensingmentioning

confidence: 99%

Review—Recent Advances of Micro/Nano-Motor-Facilitated Electrochemical Sensor Development

Mitra,

Basak,

Saini

2024

J. Electrochem. Soc.

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Micro/-nano motors (MNMs) are deployed to perform cutting edge research and development activities that include biomedical engineering, environment monitoring, energy harvesting, and more. MNMs progressively strive for miniaturization of MNMs, mightier self-propulsion, precision of motion, and smarter motion control. The last decade saw several published reports on biosensing applications of MNMs targeting enhanced specificity and selectivity. Among MNM mediated biosensors, the electrochemical biosensor is the most important stake holder. Motion of MNMs enable active transport, augmented reaction kinetics, and better selectivity causing smarter biosensing. This review explores the most advanced development of electrochemical biosensing deploying MNMs that took place in the recent past. Briefly, we cover chronological development in the field of MNM mediated electrochemical biosensing with emphasis on, conventional working electrode based sensing, DNA walker modificaitons, MNM based real time electrochemical signal monitoring, and scope of MNM mediated electrochemical sensing for intracellular monitoring or drug delivery. Conclusively, the review considers the most recent development in the field of MNM mediated electrochemical sensing that includes both in vitro and in vivo electrochemical biosensing. Additionally, we discuss use of electorchemical redox reactions for imparting motion to the MNMs in physiological fluids for intracellular manipulation, targeted drug delivery, and more.

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Section: Discussion On Role Of Mnms In Electrochemical Biosensingmentioning

confidence: 99%

Review—Recent Advances of Micro/Nano-Motor-Facilitated Electrochemical Sensor Development

Mitra,

Basak,

Saini

2024

J. Electrochem. Soc.

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“…The human body is an extremely complex system with sophisticated barriers that protect it from external threats. To effectively reach the targeted area and exert their therapeutic effects, MNMs must travel through challenging environments and overcome barriers, e.g., mucus, 58,59 blood brain barrier, 60 skin, 61,62 and eye vitreous. 63 Moreover, evaluating therapeutic outcomes in a real body system is more challenging compared to simple in vitro cell models.…”

Section: Biomedical Applications Of Mnmsmentioning

confidence: 99%

Enzymatic micro/nanomotors in biomedicine: from single motors to swarms

Chen,

Prado-Morales,

Sánchez-deAlcázar

et al. 2024

J. Mater. Chem. B

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Micro/Nanorobots for Advanced Light‐Based Biosensing and Imaging

Neettiyath,

Pumera

2024

Adv Funct Materials

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Sensing and imaging of biomolecules are crucial to disease diagnosis, prognosis, and therapy where optical techniques have essential utility. Untethered and remotely controlled micro/nanorobots have shown promising sensing and imaging capabilities, especially in complex biological environments. In this review, how micro/nanorobots are used for optical biosensing and imaging while highlighting the significant developments in the field is discussed. Starting is done by exploring colorimetric biosensing methods enabled by micro/nanorobots. Significant advancements in surface‐enhanced Raman spectroscopy‐integrated micro/nanorobots are reviewed. Further, state‐of‐the‐art optical bio‐imaging applications by micro/nanorobots at in vitro intracellular level are highlighted. Novel in vivo bio‐imaging assisted by optical micro/nanorobot sensors is examined. Furthermore, innovations in micro/nanorobots are assessed where motion augmentation is used as a detection mechanism, with applications in point‐of‐care molecular diagnostics. Finally, the challenges associated with micro/nanorobots‐assisted advanced optical biosensing and imaging while discussing insights about potential research directions for this rapidly progressing field are summarized.

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Lipase-powered asymmetric silica nanomotors with a tailored head-tail structure for enhanced mucus penetration

Cited by 4 publications

References 35 publications

Review—Recent Advances of Micro/Nano-Motor-Facilitated Electrochemical Sensor Development

Review—Recent Advances of Micro/Nano-Motor-Facilitated Electrochemical Sensor Development

Enzymatic micro/nanomotors in biomedicine: from single motors to swarms

Micro/Nanorobots for Advanced Light‐Based Biosensing and Imaging

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