“…In other viral settings, orlistat and metformin were shown to inhibit replication of several flaviviruses [109][110][111][112], as well as hepatitis B virus and HCV [113][114][115][116][117], coxsackievirus B3 and varicella-zoster virus [118,119]. For these viruses, orlistat was shown to inhibit lipid-vesicle restructuring, viral genome replication, virion protein palmitoylation [109][110][111]118] and virus entry [113,114]. Metformin was shown to decrease lipid (palmitate) synthesis [119], viral RNA transcription and protein synthesis [115,116], as well as virus-dependent glycolysis, while increasing IFN production and blocking inflammatory cytokines [112,117].…”