Abstract:The influences of water activity and solvent hydrophobicity on the kinetics of the lipase-catalyzed enantioselective esterification of flurbiprofen with nbutanol were investigated. The solvent effect was not similar for lipases from Candida rugosa (Crl), Mucor javanicus (Mjl), and porcine pancreas (Ppl). The lipasecatalyzed reaction rates in different solvents across a wide range of water activities revealed that the Pplcatalyzed reaction exhibited no enantioselectivity and no substantial water activity or sol… Show more
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