Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

Hernández-Morales, Antonio; González-López, Blanca Silvia; Scougall‐Vilchis, Rogelio José; Bermeo-Escalona, Josué Roberto; Velazquez-Enriquez, Ulises; Islas-Zarazúa, Rosalina; Márquez-Rodríguez, Sonia; Sosa-Velasco, Taurino Amílcar; Medina-Solís, Carlo Eduardo; Maupomé, Gerardo

doi:10.3390/healthcare11081063

Cited by 14 publications

(5 citation statements)

References 40 publications

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“…However, a deeper analysis revealed that the highest burden of cancer occurred in countries with moderate and low HDI, suggesting a poorer survival prognosis. 31 A previous study on lip and oral cavity cancer (LOCC) 32 followed the same methodology. It found correlations between various socioeconomic indicators and tobacco use, with LOCC incidence and mortality.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Mortality of Salivary Gland Cancer Worldwide and Its Correlation with Tobacco Use (Smoking and Chewing) and With the Human Development Index

Hernández-Morales,

González-López,

Scougall-Vilchis

et al. 2024

Journal of Advanced Oral Research

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Objective: The aim of this study was to quantify the association between the incidence and mortality of salivary gland cancer (SGC) with the consumption of tobacco and with the Human Development Index (HDI). Material and Methods: An ecological study was designed using SGC incidence and mortality data in 172 countries in 2020, reported per 100,000 population with an age range of 10–85 years. Such dependent variables were obtained from the Global Cancer Observatory (GLOBOCAN). The prevalences of smoked and chewed tobacco were obtained from reports made in 2019, sourced from Global Burden of Diseases Study, while the HDI was obtained from the Human Development Report (2019) presented by the United Nations Development Program, and were considered independent variables. Statistical analysis was performed in Stata using Spearman’s correlation test. Results: In 2020, there were 53,583 new cases of SGC worldwide, and countries with very high HDI exhibited a higher incidence. In terms of mortality, there were 22,778 cases worldwide, and countries with a moderate HDI showed a higher number of deaths. SGC mortality was associated with chewing tobacco use overall and in women. Surprising negative associations were found with the incidence of SGC and tobacco smoking in men, as well as with mortality of SGC and smoking overall and in women. CGS mortality was negatively associated with the HDI and all its components. Conclusion: In this international overview, SGC mortality is associated with chewing tobacco in women, as well as with the HDI and its components.

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Section: Discussionmentioning

confidence: 99%

Incidence and Mortality of Salivary Gland Cancer Worldwide and Its Correlation with Tobacco Use (Smoking and Chewing) and With the Human Development Index

Hernández-Morales,

González-López,

Scougall-Vilchis

et al. 2024

Journal of Advanced Oral Research

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“…It is generally accepted that low SEP is strongly associated with adverse behavioral, general health and oral health outcomes among children worldwide, and, in fact, is partially responsible for these effects [29][30][31][32][33]. Although previous studies have established SEP as a potent determinant of health, the biological mechanisms underlying this relationship are not fully understood [34].…”

Section: Discussionmentioning

confidence: 99%

Self-reported dental pain in Mexican schoolchildren: a national ecological study

2024

JOCPD

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The objective of this study was to quantify the prevalence of and identify the factors associated with dental pain among elementary-and middle-school students in Mexico. An ecological study was carried out with data from the 2008 National School-based Student-Health Survey. Information on dental pain from schoolchildren (aged 5 to 16 years) was collected from public schools across the 32 states of Mexico. In the original study, a questionnaire was used to explore various factors that affect the oral and dental health status of schoolchildren. The outcome variable was the prevalence rate (for dental pain) reported at state level. Various contextual socioeconomic variables were included, in addition to dental caries. Analyses were performed using Stata software. 52.9% of interviewees were girls; 26.9% of male and female schoolchildren in Mexico experienced gum or dental pain during the period analyzed (95% Confidence Interval = 26.02, 27.77%); according to the Spearman correlation results, self-reported dental pain was unrelated (p > 0.05) to the socioeconomic and sociodemographic variables that make up the Gross Domestic Product (GDP) and the Human Development (HDI), as well as the marginalization and the Gini indices. However, the estimated percentages of selfreported dental pain and caries were positively correlated in the elementary-(r = 0.8958, p < 0.0001), middle-school (r = 0.8958, p < 0.0001) and total populations (r = 0.8542, p < 0.0001). Prevalence of self-reported dental pain was 28%, or about one in three, of the Mexican children and adolescents in the study sample. The state-level sociodemographic and socioeconomic risk indicators were not associated with the prevalence of dental pain. Self-reported caries was positively correlated with self-reported dental pain.

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“…With increasing incidence and mortality rates, oral cancers rank as the 13th most common cancer worldwide, with an estimated 377,713 new cases and 177,757 deaths in 2020. 28 , 29 The consumption of tobacco and areca nut significantly increases the risk of oral cancers. Specifically, oral cancers cause larger burdens in developing countries due to delayed diagnosis and limited treatment opportunities.…”

Section: Exosomes In the Progression Of Oral Diseasesmentioning

confidence: 99%

“…Specifically, oral cancers cause larger burdens in developing countries due to delayed diagnosis and limited treatment opportunities. 29 Among all the types of oral cancers, OSCCs are the most common, with an estimated 40% higher incidence rate in 2040. 30 Summarizing the alterations in the exosomes in OSCCs could enhance our understanding of malignant progression.…”

Section: Exosomes In the Progression Of Oral Diseasesmentioning

confidence: 99%

Emerging roles of exosomes in oral diseases progression

Wang,

Jing,

Zhou

et al. 2024

Int J Oral Sci

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Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient’s digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients’ prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. Exosomes, which are characterized as nanometer-sized extracellular vesicles, are secreted by virtually all types of cells. As the research continues, the complex roles of these intracellular-derived extracellular vesicles in biological processes have gradually unfolded. Exosomes have attracted attention as valuable diagnostic and therapeutic tools for their ability to transfer abundant biological cargos and their intricate involvement in multiple cellular functions. In this review, we provide an overview of the recent applications of exosomes within the field of oral diseases, focusing on inflammation-related bone diseases and oral squamous cell carcinomas. We characterize the exosome alterations and demonstrate their potential applications as biomarkers for early diagnosis, highlighting their roles as indicators in multiple oral diseases. We also summarize the promising applications of exosomes in targeted therapy and proposed future directions for the use of exosomes in clinical treatment.

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Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

Cited by 14 publications

References 40 publications

Incidence and Mortality of Salivary Gland Cancer Worldwide and Its Correlation with Tobacco Use (Smoking and Chewing) and With the Human Development Index

Incidence and Mortality of Salivary Gland Cancer Worldwide and Its Correlation with Tobacco Use (Smoking and Chewing) and With the Human Development Index

Self-reported dental pain in Mexican schoolchildren: a national ecological study

Emerging roles of exosomes in oral diseases progression

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