LIP activity in the interstimulus interval of a change detection task biases the behavioral response

Arcizet, Fabrice; Mirpour, Koorosh; Foster, Daniel J.; Charpentier, Caroline J.; Bisley, James W.

doi:10.1152/jn.00604.2015

Cited by 2 publications

(9 citation statements)

References 57 publications

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“…As we have shown previously in LIP (Arcizet et al 2015) and MT (Bisley et al 2004), the responses in both V4 and LIP were greater on change trials than on no-change trials (Fig. 5A, B).…”

Section: Discriminating Change From No-change Responses As a Functionsupporting

confidence: 87%

“…We recorded the responses of 185 (26 from animal A, 97 from animal D, and 62 from animal G) neurons from LIP. The responses during the interstimulus interval from some of these neurons have been published previously (Arcizet et al 2015). The response field eccentricities in both areas ranged from 5°t o 16°.…”

Section: Recording and Data Analysismentioning

confidence: 99%

“…We collected data from 3 male adult macaque monkeys (monkeys A, D, and G, Macaca mulatta), weighing 8-14 kg. Surgical procedures have been described previously (Mirpour et al 2009;Arcizet et al 2015). Briefly, head posts, scleral search coils, and recording cylinders were surgically implanted under general anesthesia.…”

Section: Subjectsmentioning

confidence: 99%

“…We refer to them as S1 (set-size of 1), S2 (set-size of 2), S4 (set-size 4), and S8 (setsize 8). Note that the probability of receiving a reward was equal or greater if the animal maintained fixation than if it made a saccade to one of the bars, accordingly each animal appeared to retain the default behavior of maintaining fixation when unsure (Arcizet et al 2015).…”

Section: Change Detection Taskmentioning

confidence: 99%

“…As such, the use of all trials may bias our metrics around the time of the saccade. We have previously shown that the activity in LIP during the interstimulus interval biases the animals' performance (Arcizet et al 2015). When the interstimulus interval activity was high, the animals were more likely to make a hit or false alarm and when the interstimulus interval activity was low then the animals were more likely to miss a change or make a CR.…”

Section: Neuronal Responsesmentioning

confidence: 99%

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Activity in LIP, But not V4, Matches Performance When Attention is Spread

et al. 2017

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The enhancement of neuronal responses in many visual areas while animals perform spatial attention tasks has widely been thought to be the neural correlate of visual attention, but it is unclear whether the presence or absence of this modulation contributes to our striking inability to notice changes in change blindness examples. We asked whether neuronal responses in visual area V4 and the lateral intraparietal area (LIP) in posterior parietal cortex could explain the limited ability of subjects to attend multiple items in a display. We trained animals to perform a change detection task in which they had to compare 2 arrays of stimuli separated briefly in time and found that each animal's performance decreased as function of set-size. Neuronal discriminability in V4 was consistent across set-sizes, but decreased for higher set-sizes in LIP. The introduction of a reward bias produced attentional enhancement in V4, but this could not explain the vast improvement in performance, whereas the enhancement in LIP responses could. We suggest that behavioral set-size effects and the marked improvement in performance with focused attention may not be related to response enhancement in V4 but, instead, may occur in or on the way to LIP.

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“…As we have shown previously in LIP (Arcizet et al 2015) and MT (Bisley et al 2004), the responses in both V4 and LIP were greater on change trials than on no-change trials (Fig. 5A, B).…”

Section: Discriminating Change From No-change Responses As a Functionsupporting

confidence: 87%

Section: Recording and Data Analysismentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Change Detection Taskmentioning

confidence: 99%

Section: Neuronal Responsesmentioning

confidence: 99%

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Activity in LIP, But not V4, Matches Performance When Attention is Spread

et al. 2017

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Subcortical connectivity correlates selectively with attention’s effects on spatial choice bias

Sreenivasan

Sridharan

2019

Proc. Natl. Acad. Sci. U.S.A.

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Neural mechanisms of attention are extensively studied in the neocortex; comparatively little is known about how subcortical regions contribute to attention. The superior colliculus (SC) is an evolutionarily conserved, subcortical (midbrain) structure that has been implicated in controlling visuospatial attention. Yet how the SC contributes mechanistically to attention remains unknown. We investigated the role of the SC in attention, combining model-based psychophysics, diffusion imaging, and tractography in human participants. Specifically, we asked whether the SC contributes to enhancing sensitivity (d′) to attended information, or whether it contributes to biasing choices (criteria) in favor of attended information. We tested human participants on a multialternative change detection task, with endogenous spatial cueing, and quantified sensitivity and bias with a recently developed multidimensional signal detection model (m-ADC model). At baseline, sensitivity and bias exhibited complementary patterns of asymmetries across the visual hemifields: While sensitivity was consistently higher for detecting changes in the left hemifield, bias was higher for reporting changes in the right hemifield. Remarkably, white matter connectivity of the SC with the neocortex mirrored this pattern of asymmetries. Specifically, the asymmetry in SC–cortex connectivity correlated with the asymmetry in choice bias, but not in sensitivity. In addition, SC–cortex connectivity strength could predict cueing-induced modulation of bias, but not of sensitivity, across individuals. In summary, the SC may be a key node in an evolutionarily conserved network for controlling choice bias during visuospatial attention.

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LIP activity in the interstimulus interval of a change detection task biases the behavioral response

Abstract: Arcizet F, Mirpour K, Foster DJ, Charpentier CJ, Bisley JW. LIP activity in the interstimulus interval of a change detection task biases the behavioral response.

Cited by 2 publications

References 57 publications

Activity in LIP, But not V4, Matches Performance When Attention is Spread

Activity in LIP, But not V4, Matches Performance When Attention is Spread

Subcortical connectivity correlates selectively with attention’s effects on spatial choice bias

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